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A timeline-relating IgG4 levels, clinical features and immunosuppressive therapy are presented. The protean and relapsing\u2013remitting nature of this condition is emphasised, and a brief review of long-term therapeutic options is provided.<\/jats:p>","DOI":"10.1136\/bcr-2017-219897","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T01:55:14Z","timestamp":1500256514000},"page":"bcr-2017-219897","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["IgG4-related disease: long-term natural history and management of a relapsing multisystem disease entity"],"prefix":"10.1136","volume":"2017","author":[{"given":"Sreelakshmi","family":"Kotha","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Guy\u2019s and Saint Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Tritto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guy\u2019s and Saint Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guy\u2019s and Saint Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guy\u2019s and Saint Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,7,16]]},"reference":[{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0386-x"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01531.x"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.010"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.4","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-4-23"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21700"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02092.x"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.7","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182431ef6"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/602809","article-title":"Pathologies Associated with Serum IgG4 Elevation","volume":"2012","author":"Ebbo","year":"2012","journal-title":"Int J Rheumatol"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.9","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000680","article-title":"IgG4-related disease: dataset of 235 consecutive patients","volume":"94","author":"Inoue","year":"2015","journal-title":"Medicine"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis193"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.12","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205233"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.03.021"},{"key":"2025082701410850000_2017.jul16_1.bcr-2017-219897.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-0945-z"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-219897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:41:21Z","timestamp":1756284081000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-219897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,16]]},"references-count":14,"alternative-id":["10.1136\/bcr-2017-219897"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-219897","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,16]]}}}