{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:32:43Z","timestamp":1775817163141,"version":"3.50.1"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,5,11]]},"abstract":"<jats:p>A 63-year-old man presented with right-sided hemianopia and unsteady gait. Brain MRI revealed multiple hyperintense infarct-like lesions on diffusion-weighted images (DWI). Hyperintensity persisted in some of these lesions even after 6 weeks, although his symptoms were ameliorated then. The patient developed episodic dizziness and a transient event of apraxia at 18 weeks after the first episode. Brain MRI revealed additional hyperintense lesions on DWI, which persisted even after 7 weeks. Eventually, the patient manifested cauda equina syndrome 39 weeks after the first episode. Brain MRI showed the presence of new lesions in addition to the persistent hyperintense lesions on DWI over 21 weeks in the right frontal lobe. Based on laboratory findings and the pathological assessment of bone marrow and random skin biopsies, the patient was diagnosed with intravascular lymphoma (IVL). Persistent hyperintense lesions on DWI of brain MRI may precede the clinical exacerbation of IVL.<\/jats:p>","DOI":"10.1136\/bcr-2017-220099","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T10:55:24Z","timestamp":1496919324000},"page":"bcr-2017-220099","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Persistent lesion hyperintensity on brain diffusion-weighted MRI is an early sign of intravascular lymphoma"],"prefix":"10.1136","volume":"2017","author":[{"given":"Takashi","family":"Kageyama","sequence":"first","affiliation":[{"name":"Department of Neurology, Tenri Hospital, Tenri, Japan"},{"name":"Department of Neurology, Tokai Memorial Hospital, Kasugai, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tenri Hospital, Tenri, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tenri Hospital, Tenri, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Suenaga","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tenri Hospital, Tenri, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2770"},{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.046383"},{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.033662"},{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000362121","article-title":"Intravascular lymphomatosis mimicking primary central nervous system lymphoma: a case report and literature review","volume":"6","author":"Oomura","year":"2014","journal-title":"Case Rep Neurol"},{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jns.2016.08.051","article-title":"An autopsy case of intravascular large B-cell lymphoma with subcortical U-fiber sparing and unique lymphocyte markers","volume":"369","author":"Sato","year":"2016","journal-title":"J Neurol Sci"},{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s10147-008-0823-x","article-title":"Standardized uptake value on FDG-PET as a marker for disease activity in patients with non-Hodgkin's lymphoma: comparison with serum soluble interleukin-2 receptor values","volume":"14","author":"Tatsumi","year":"2009","journal-title":"Int J Clin Oncol"},{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.01008.x"},{"key":"2025082702534171000_2017.jun08_1.bcr-2017-220099.8","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.2147\/OTT.S72596","article-title":"Long-term complete remission in a patient with intravascular large B-cell lymphoma with central nervous system involvement","volume":"7","author":"Sawada","year":"2014","journal-title":"Onco Targets Ther"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-220099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:53:51Z","timestamp":1756288431000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-220099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,8]]},"references-count":8,"alternative-id":["10.1136\/bcr-2017-220099"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-220099","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,8]]}}}