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We will illustrate a challenging case of a patient with CPAN who developed gangrenous infarcts despite initial immunosuppressive treatment with high-dose steroids and azathioprine. His treatment had to be escalated to intravenous cyclophosphamide which induced disease remission<\/jats:p>","DOI":"10.1136\/bcr-2017-220300","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T10:45:27Z","timestamp":1498733127000},"page":"bcr-2017-220300","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Gangrenous digital infarcts in a severe case of cutaneous polyarteritis nodosa"],"prefix":"10.1136","volume":"2017","author":[{"given":"Hamzah","family":"Mahmood-Rao","sequence":"first","affiliation":[{"name":"Royal Derby Hospital, Derby, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Ding","sequence":"additional","affiliation":[{"name":"Royal Derby Hospital, Derby, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirav","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Royal Derby Hospital, Derby, 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