{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:13:21Z","timestamp":1789726401777,"version":"4.0.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,7,13]]},"abstract":"<jats:p>Acute generalised exanthematous pustulosis (AGEP) is a rare cutaneous eruption, most often caused by commonly used antibiotics. It is characterised by an acute onset of non-follicular sterile pustular rash and erythema within hours or days of drug exposure and usually resolves spontaneously within 1\u20132 weeks once the drug is discontinued. Haemodynamic involvement in the form of shock is rare. Here, we present a severe case of AGEP, manifesting with systemic involvement and haemodynamic instability resulting in shock with multiorgan dysfunction. The associated drugs were erythromycin and fluconazole with a possible combined effect of these two drugs that resulted in systemic involvement. Our patient improved markedly, both haemodynamically and dermatologically, after discontinuation of the drugs and with systemic steroid therapy.<\/jats:p>","DOI":"10.1136\/bcr-2017-220612","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T10:40:14Z","timestamp":1501670414000},"page":"bcr-2017-220612","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["An illusion of septic shock: acute generalised exanthematous pustulosis with multiorgan dysfunction"],"prefix":"10.1136","volume":"2017","author":[{"given":"Manisha","family":"Jakkidi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Basmadjian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyajeet","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital, Cherry Hill, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028003113.x"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08156.x"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680080069004"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.4","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.163"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.5","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-4632.2010.04313.x","article-title":"Acute generalized exanthematous pustulosis: analysis of cases managed in a tertiary hospital in Singapore","volume":"49","author":"Lee","year":"2010","journal-title":"Int J Dermatol"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1684\/ejd.2010.0932","article-title":"Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts","volume":"20","author":"Speeckaert","year":"2010","journal-title":"Eur J Dermatol"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40560-015-0114-3","article-title":"Vancomycin-induced acute generalized exanthematous pustulosis (AGEP) masquerading septic shock-an unusual presentation of a rare disease","volume":"3","author":"Mawri","year":"2015","journal-title":"J Intensive Care"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.8","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2013987"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2340\/00015555-0438","article-title":"Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in Asia","volume":"88","author":"Chang","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"2025082802513309000_2017.aug01_1.bcr-2017-220612.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.017"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-220612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:51:40Z","timestamp":1756374700000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-220612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":10,"alternative-id":["10.1136\/bcr-2017-220612"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-220612","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]}}}