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In view of the comorbidities, locally recurrent disease and presence of right Iliac lymphadenopathy, the patient was treated with nanosomal docetaxel lipid suspension (NDLS), cisplatin and 5-fluorouracil (TPF regimen) in the neoadjuvant setting followed by staged surgical resection. This is the first case report showing successful treatment of recurrent pSCC with NDLS-based TPF regimen in the neoadjuvant setting followed by staged surgery in a patient with poorly controlled diabetes.<\/jats:p>","DOI":"10.1136\/bcr-2017-220686","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T02:00:15Z","timestamp":1510538415000},"page":"bcr-2017-220686","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Successful downstaging of locally recurrent penile squamous cell carcinoma with neoadjuvant nanosomal docetaxel lipid suspension (NDLS) based regimen followed by curative surgery"],"prefix":"10.1136","volume":"2017","author":[{"given":"Sameer","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashi Singh","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Bunger","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs and Clinical Research, Intas Pharmaceuticals Limited, Ahmedabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,11,12]]},"reference":[{"key":"2025082722415846000_2017.nov11_2.bcr-2017-220686.1","doi-asserted-by":"crossref","unstructured":"Crook J , Mazeron J , cancer P . 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