{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:43:10Z","timestamp":1765960990424,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,6,16]]},"abstract":"<jats:p>Epstein-Barr virus mucocutaneous ulcer (EBVMCU) is a rare form of EBV lymphoproliferative disorder. The disease was recently described in 2010 for the first time in a case series and it was recently identified by the WHO classification of haematological malignancies as a separate category among the EBV lymphoproliferative disorders. We present a case of EBVMCU of the colon presenting as an ulcerating inflammatory mass in a female in her mid-60s who presented initially with abdominal pain and diarrhoea. The patient had extensive workup for her disease and due to progression of her symptoms, she was taken for an exploratory laparotomy. During the procedure, there was an inflammatory mass at the caecum and severe inflammation of the caecum and the terminal ileum and right hemicolectomy was performed. Diagnosis was confirmed by histopathology as EBV-positive lymphoproliferative disorder best classified as EBV-positive mucocutaneous ulcer.<\/jats:p>","DOI":"10.1136\/bcr-2017-220717","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T23:50:30Z","timestamp":1499385030000},"page":"bcr-2017-220717","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["A rare case of Epstein-Barr virus mucocutaneous ulcer of the colon"],"prefix":"10.1136","volume":"2017","author":[{"given":"Mohammed","family":"Osman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al Salihi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Abu Sitta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hurley Medical Center, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-8042","authenticated-orcid":false,"given":"Samer","family":"Al Hadidi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hurley Medical Center \/Michigan State University, Flint, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf8622"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.2","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1182\/blood-2010-12-323238","article-title":"Age-related EBV-associated lymphoproliferative disorders in the Western population : a spectrum of reactive lymphoid hyperplasia\u00a0and lymphoma age-related EBV-associated lymphoproliferative disorders in the Western population : a spectrum of reactive lymph","volume":"117","author":"Dojcinov","year":"2012","journal-title":"Blood"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40164-016-0042-5","article-title":"Diagnostic and therapeutic challenges of EBV-positive mucocutaneous ulcer: a case report and systematic review of the literature","volume":"5","author":"Roberts","year":"2015","journal-title":"Exp Hematol Oncol"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/ccr3.287","article-title":"Age-related Epstein-Barr virus-positive mucocutaneous ulcer: a case report","volume":"3","author":"Magalhaes","year":"2015","journal-title":"Clin Case Rep"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.5","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.3748\/wjg.v21.i19.6072","article-title":"Epstein Barr virus-positive mucocutaneous ulcer of the colon associated Hodgkin\u00a0lymphoma in Crohn's disease","volume":"21","author":"Moran","year":"2015","journal-title":"World J Gastroenterol"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-489708"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-164806"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.9","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000282"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.10","doi-asserted-by":"publisher","DOI":"10.1086\/374739"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02555.x"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.12","doi-asserted-by":"crossref","unstructured":"Chen B-J , Fang C-L , Chuang S-S . Epstein-Barr virus-positive mucocutaneous ulcer. Kaohsiung J Med Sci 2016:2\u20133.","DOI":"10.1016\/j.kjms.2016.08.003"},{"key":"2025082801150150000_2017.jul06_2.bcr-2017-220717.13","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPNLC9NC9WTQYY"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-220717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:15:11Z","timestamp":1756368911000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-220717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,6]]},"references-count":13,"alternative-id":["10.1136\/bcr-2017-220717"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-220717","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,7,6]]}}}