{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:40:15Z","timestamp":1756287615019,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,7,28]]},"abstract":"<jats:p>Fever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis.<\/jats:p>\n               <jats:p>We present a 53-year-old male patient admitted with fever, weight loss of 15\u2009kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells\/mm<jats:sup>3<\/jats:sup> and viral load 3.172.370 copies\/mL. A body CT scan showed multiple axillary, mediastinal, lumbar, aortic, iliac and pelvic lymphadenopathy as well as hepatosplenomegaly. An excisional biopsy of the left axillary lymphadenopathy was performed and histology ultimately revealed multicentric Castleman\u2019s disease associated with Human Herpes Virus-8. After initiation of antiretroviral therapy, rituximab was given and progressive clinical improvement occurred.<\/jats:p>","DOI":"10.1136\/bcr-2017-220740","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T03:40:33Z","timestamp":1502854833000},"page":"bcr-2017-220740","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Fever and generalised lymphadenopathy in an HIV-positive patient: a diagnostic challenge"],"prefix":"10.1136","volume":"2017","author":[{"given":"Bernardo","family":"Neves","sequence":"first","affiliation":[{"name":"Internal Medicine, Hospital da Luz, Lisboa, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Raimundo","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hospital da Luz, Lisboa, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Farinha","sequence":"additional","affiliation":[{"name":"Pathology Anatomy, Centro Hospitalar de Lisboa Central EPE, Lisboa, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/00365548.2010.498016","article-title":"Tuberculosis is the leading cause of lymphadenopathy in HIV-infected persons in India: results of a fine-needle aspiration analysis","volume":"42","author":"Kamana","year":"2010","journal-title":"Scand J Infect Dis"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1468-1293.2012.01035.x","article-title":"Clinical predictors for the aetiology of peripheral lymphadenopathy in HIV-infected adults","volume":"14","author":"Bogoch","year":"2013","journal-title":"HIV Med"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-012-9440-6"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.7835"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)00983-5"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.002691"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.08.004"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)01020-8"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05311.x"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.10","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn697"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.11","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199601000-00009"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2331"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.13","doi-asserted-by":"crossref","unstructured":"Wang H-W , Pittaluga S , Jaffe ES . Multicentric Castleman disease\u2014where are we now? seminars in diagnostic pathology. Elsevier 2016:1\u201333.","DOI":"10.1053\/j.semdp.2016.05.006"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.1909"},{"key":"2025082701591645000_2017.aug13_1.bcr-2017-220740.15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.6732"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-220740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:59:23Z","timestamp":1756285163000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-220740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":15,"alternative-id":["10.1136\/bcr-2017-220740"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-220740","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,8,16]]}}}