{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:26Z","timestamp":1756339346404,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,10,5]]},"abstract":"<jats:p>Severe carcinoid syndrome and carcinoid heart disease in neuroendocrine tumours can have a significant impact on a patient\u2019s quality of life and are a major cause of morbidity and mortality. We present a novel approach to managing a patient with medically uncontrollable carcinoid syndrome. Inferior and superior vena cava placement of transcatheter heart valves has been used to treat patients with right heart failure due to severe tricuspid and pulmonary regurgitation. However, this procedure has not been attempted to specifically reduce hormone secretion, primarily from the liver, in order to control carcinoid syndrome symptoms. We attempted this procedure in a patient with severe carcinoid disease and tricuspid regurgitation as a bridge to later definitive therapy. The procedure was technically successful, but did not improve carcinoid symptoms. The possible reasons for the failure are discussed here.<\/jats:p>","DOI":"10.1136\/bcr-2017-220888","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T01:30:13Z","timestamp":1508808613000},"page":"bcr-2017-220888","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Transcatheter valve implantation to inferior vena cava to control carcinoid symptoms"],"prefix":"10.1136","volume":"2017","author":[{"given":"Vandana M","family":"Sagar","sequence":"first","affiliation":[{"name":"Department of Liver Medicine, University Hospitals Birmingham, NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P","family":"Steeds","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals Birmingham, NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar N","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals Birmingham, NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Liver Medicine, University Hospitals Birmingham, NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.653584"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300831"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.701367"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.4","first-page":"E4","article-title":"Utility of 3D transoesophageal echocardiography for the assessment of tricuspid and pulmonary valves in carcinoid heart disease","volume":"12","author":"Bhattacharyya","year":"2011","journal-title":"Eur J Echocardiogr"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.5","doi-asserted-by":"publisher","DOI":"10.4250\/jcu.2011.19.2.99"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.08.045"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp474"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.11.019"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.070"},{"issue":"3-4","key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000437167","article-title":"Staged catheter-based value treatment of severe carcinoid heart disease","volume":"103","author":"Laule","year":"2016","journal-title":"Neuroendocrinology"},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.11","unstructured":"Stangl K . National Library of Medicine(US) 2015 Feb 27 \u2013 Identifier NCT02387697, Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve (TRICAVAL). ClincalTrials.gov [Internet]."},{"key":"2025082623262675000_2017.oct21_1.bcr-2017-220888.12","unstructured":"Neill O . National Library of Medicine (US) 2015 Jan 13 - Identifier NCT02339974. Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER) (HOVER). ClincalTrials.gov\u00a0[Internet]."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-220888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:26:36Z","timestamp":1756275996000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-220888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":12,"alternative-id":["10.1136\/bcr-2017-220888"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-220888","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}