{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:56:33Z","timestamp":1790704593857,"version":"4.1.0"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,8,5]]},"abstract":"<jats:p>Pulmonary tumour thrombotic microangiopathy (PTTM) is a rare complication of cancer, which can be lethal due to progressive pulmonary hypertension (PH). Several case reports have demonstrated that imatinib, a platelet-derived growth factor receptor\u2013tyrosine kinase inhibitor, can improve severe PH in patients with PTTM.<\/jats:p><jats:p>We describe the case of a 56-year-old woman. Her mean pulmonary arterial pressure (mPAP) was 47\u2009mm Hg, and her dyspnoea worsened rapidly over several days. Although pulmonary embolism was not observed on CT, enlargement of the para-aortic lymph nodes was detected. Gastro-oesophageal endoscopy revealed signet-ring cell carcinoma. We diagnosed her as having PTTM based on her clinical course, and started treatment with imatinib. Five days after its administration, her mPAP decreased dramatically. She was discharged and lived without symptoms of PH until her death due to systemic metastasis of carcinoma. In some cases of PTTM, imatinib may be an effective therapeutic option for PH.<\/jats:p>","DOI":"10.1136\/bcr-2017-221032","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T10:42:52Z","timestamp":1504780972000},"page":"bcr-2017-221032","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Imatinib dramatically alleviates pulmonary tumour thrombotic microangiopathy induced by gastric cancer"],"prefix":"10.1136","volume":"2017","author":[{"given":"Kana","family":"Kubota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<587::AID-CNCR2820660330>3.0.CO;2-J"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10388-013-0382-8","article-title":"A case report of pulmonary tumor thrombotic microangiopathy (PTTM) caused by esophageal squamous cell carcinoma","volume":"10","author":"Fujishiro","year":"2013","journal-title":"Esophagus"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.536169"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.4","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000201359.58174.c8"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/FJC.0b013e3181c0419c","article-title":"Inhibitory effects of simvastatin on platelet-derived growth factor signaling in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension","volume":"55","author":"Ikeda","year":"2010","journal-title":"J Cardiovasc Pharmacol"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.6","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0718"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000765"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20973"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.9","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.075739"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.10","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.14-220"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.11","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.2379"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2014.10.008"},{"key":"2025042712363359000_2017.sep06_1.bcr-2017-221032.13","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1186\/s40064-016-3280-4","article-title":"Imatinib could be a new strategy for pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy in metastatic breast cancer","volume":"5","author":"Fukada","year":"2016","journal-title":"Springerplus"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T19:36:36Z","timestamp":1745782596000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,7]]},"references-count":13,"alternative-id":["10.1136\/bcr-2017-221032"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221032","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,7]]}}}