{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:00:39Z","timestamp":1789984839245,"version":"4.0.1"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,8,8]]},"abstract":"<jats:p>Primary sclerosing cholangitis (PSC) is a liver disease that leads to progressive destruction and stricturing of the biliary tree. Unfortunately, apart from orthotopic liver transplantation (OLT), there are no universally accepted therapies to treat this disease. Even following transplantation, recurrence of PSC is seen in approximately one quarter of patients and leads to high rates of graft failure. Oral vancomycin, through possible immunomodulatory and anti-inflammatory mechanisms, has been shown in small-scale studies to be successful in improving liver function tests in patients with pretransplant PSC. We report the first case of an adult patient diagnosed with recurrent PSC 4\u2009years after OLT who was treated with oral vancomycin leading to complete normalisation of his liver biochemistry. This case adds to the growing literature of a potential therapeutic role for this antibiotic in PSC and highlights interesting questions regarding mechanisms of disease.<\/jats:p>","DOI":"10.1136\/bcr-2017-221165","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T03:05:13Z","timestamp":1506395113000},"page":"bcr-2017-221165","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of oral vancomycin in recurrent primary sclerosing cholangitis following liver transplantation"],"prefix":"10.1136","volume":"2017","author":[{"given":"Penelope","family":"Hey","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lokan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gow","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"2025082701170151000_2017.sep25_1.bcr-2017-221165.1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23294"},{"key":"2025082701170151000_2017.sep25_1.bcr-2017-221165.2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21260"},{"key":"2025082701170151000_2017.sep25_1.bcr-2017-221165.3","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jhep.2015.07.005","article-title":"Risk factors for recurrent primary sclerosing cholangitis after liver transplantation","volume":"63","author":"Ravikumar","year":"2015","journal-title":"J Hepatol"},{"key":"2025082701170151000_2017.sep25_1.bcr-2017-221165.4","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12232"},{"key":"2025082701170151000_2017.sep25_1.bcr-2017-221165.5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.15403\/jgld.2014.1121.254.rah","article-title":"A triple blinded, randomized, placebo-controlled clinical trail to evaluate the efficacy and safety of oral vancomycin in primary sclerosing cholangitis: A pilot study","volume":"25","author":"Rahimpour","year":"2016","journal-title":"J Gastrointest Liver Dis"},{"key":"2025082701170151000_2017.sep25_1.bcr-2017-221165.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9801-1"},{"key":"2025082701170151000_2017.sep25_1.bcr-2017-221165.7","first-page":"1","article-title":"Successful treatment of recurrent primary sclerosing cholangitis after orthotopic liver transplantation with oral vancomycin","volume":"2013","author":"Davies","year":"2013","journal-title":"Case Rep Transplant"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:17:11Z","timestamp":1756282631000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,25]]},"references-count":7,"alternative-id":["10.1136\/bcr-2017-221165"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221165","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,25]]}}}