{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:36:32Z","timestamp":1767713792418,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,9,12]]},"abstract":"<jats:p>Interferon-alpha (IFN-\u03b1) is an effective drug used for the treatment of chronic hepatitis C. So far its numerous side effects have been reported in the literature. It may be difficult to always put IFN-induced thyroid diseases into a single classic thyroid disease table. There are numerous atypical thyroid diseases due to IFN usage for hepatitis C virus. Herein, we present a case with a rare clinical table such as thyrotoxicosis observed following IFN-\u03b1 therapy in a patient with euthyroid nodular thyroid without autoimmune thyroiditis findings and the use of therapeutic apheresis method for the treatment of disease.<\/jats:p>","DOI":"10.1136\/bcr-2017-221228","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T03:05:23Z","timestamp":1506395123000},"page":"bcr-2017-221228","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Interferon alpha-induced non-immune thyrotoxicosis treated by plasmapheresis"],"prefix":"10.1136","volume":"2017","author":[{"given":"Zeynel Abidin","family":"Sayiner","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Gaziantep University, Gaziantep, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayten","family":"Erayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylan","family":"Metin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesut","family":"\u00d6zkaya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Gaziantep University, Gaziantep, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1590\/S1807-59322010000700016","article-title":"Expectoration of large bronchial casts secondary to the treatment of chronic hepatitis C with pegylated interferon and ribavirin","volume":"65","author":"Ara\u00fajo","year":"2010","journal-title":"Clinics"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.2","doi-asserted-by":"publisher","DOI":"10.1089\/105072503322238809"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.07.001"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.4","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02104"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1507\/endocrj.52.293","article-title":"Graves' hyperthyroidism showing transient hypothyroidism during interferon therapy for chronic hepatitis type C","volume":"52","author":"Inoue","year":"2005","journal-title":"Endocr J"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80184-X"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.7","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1320587"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.07.001"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1173"},{"key":"2025082702554322000_2017.sep25_1.bcr-2017-221228.10","unstructured":"Akeno N , Tomer Y . Dissecting the mechanisms of interferon-induced thyroiditis (IIT): direct efects of interferon alpha on thyroid epithelial cells. In: 89th Annual Meeting of the Endocrine Society. 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