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A subsequent gastrointestinal workup including oesophageal manometry and oesophagogastroduodenoscopy revealed elevated lower oesophageal pressures and histopathology suggestive of mast cell proliferation, respectively. These findings were suggestive of oesophageal mastocytosis. Treatment with omeprazole-sodium bicarbonate, cetirizine, montelukast and oral budesonide promptly ameliorated his symptoms which have not recurred.<\/jats:p>","DOI":"10.1136\/bcr-2017-221276","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T01:05:15Z","timestamp":1503968715000},"page":"bcr-2017-221276","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Oesophageal mastocytosis: eosinophilic oesophagitis without eosinophils?"],"prefix":"10.1136","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0906-7466","authenticated-orcid":false,"given":"Donevan","family":"Westerveld","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Glover","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12325"},{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00685.x"},{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.3","first-page":"70","article-title":"Alterations of mast cells in the esophageal mucosa of the patients with non-erosive reflux disease","volume":"4","author":"Yu","year":"2011","journal-title":"Gastroenterology Res"},{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5009\/gnl14294","article-title":"Esophageal mast cell infiltration in a 32-year-old woman with noncardiac chest pain","volume":"10","author":"Lee","year":"2016","journal-title":"Gut Liver"},{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.5","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/dote.12231","article-title":"Esophageal mucosal mast cell infiltration and changes in segmental smooth muscle contraction in noncardiac chest pain","volume":"28","author":"Park","year":"2015","journal-title":"Dis Esophagus"},{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1442-2050.2010.01127.x","article-title":"ERK1\/2 signaling pathway in mast cell activation-induced sensitization of esophageal nodose C-fiber neurons","volume":"24","author":"Gao","year":"2011","journal-title":"Dis Esophagus"},{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.7","first-page":"759","article-title":"A Review of esophageal chest pain","volume":"11","author":"Coss-Adame","year":"2015","journal-title":"Gastroenterol Hepatol"},{"key":"2025082800590056000_2017.aug28_3.bcr-2017-221276.8","first-page":"S6","article-title":"The pathophysiology of non-cardiac chest pain","volume":"20 Suppl","author":"Van Handel","year":"2005","journal-title":"J Gastroenterol Hepatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:59:08Z","timestamp":1756367948000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,28]]},"references-count":8,"alternative-id":["10.1136\/bcr-2017-221276"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221276","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,8,28]]}}}