{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:35:47Z","timestamp":1781894147065,"version":"3.54.5"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,5,25]]},"abstract":"<jats:p>Plasma cell mucositis (PCM) is a rare non-neoplastic plasma cell proliferative disorder of the mucous membranes, which typically presents as soft tissue lesions involving oral, upper airway or genital mucosa. Laryngeal involvement resulting in stridor has been reported in four other cases previously, with three requiring tracheostomy. We present a case of supraglottic stenosis in a 53-year-old woman presenting with dysphonia and stridor, requiring surgical resection on three occasions accompanied by tracheostomy on two occasions; biopsy was consistent with PCM. Due to relapsing disease activity, high-dose prednisolone and mycophenolate mofetil were commenced with prednisolone eventually being ceased. After 2 years of mycophenolate mofetil therapy, the patient\u2019s disease has been controlled without need for further surgical intervention. This is the first reported case of prolonged symptomatic improvement with the use of systemic immunosuppressive therapy with mycophenolate mofetil in PCM.<\/jats:p>","DOI":"10.1136\/bcr-2017-221333","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T04:05:37Z","timestamp":1529553937000},"page":"bcr-2017-221333","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Long-term control of laryngeal plasma cell mucositis with systemic immunosuppression"],"prefix":"10.1136","volume":"2018","author":[{"given":"James","family":"Triplett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Hee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McLean-Tooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.08.016"},{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bjoms.2009.10.030","article-title":"Squamous cell carcinoma arising in mucosal plasmacytosis","volume":"48","author":"Pepper","year":"2010","journal-title":"Br J Oral Maxillofac Surg"},{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4155\/cli.12.120","article-title":"Assessment and management of mucositis in head and neck cancer patients","volume":"2","author":"Bonomi","year":"2012","journal-title":"Clin Investig"},{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00404-8"},{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199410000-00008"},{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0030-4220(91)90428-F","article-title":"Association of supraglottic and gingival idiopathic plasmacytosis","volume":"71","author":"Timms","year":"1991","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.7","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1258\/0022215011909396","article-title":"Plasma cell infiltration of the upper aerodigestive tract treated with radiation therapy","volume":"115","author":"Fogarty","year":"2001","journal-title":"J Laryngol Otol"},{"key":"2025042703565009000_2018.jun20_1.bcr-2017-221333.8","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1017\/S0022215112001922","article-title":"Balloon dilatation to treat plasmacytosis of the supraglottic larynx","volume":"126","author":"Mistry","year":"2012","journal-title":"J Laryngol Otol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:57:00Z","timestamp":1745751420000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,20]]},"references-count":8,"alternative-id":["10.1136\/bcr-2017-221333"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221333","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,20]]}}}