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Biopsy of the left thigh muscle showed necrotic thrombus with fungal hyphae in the clotted blood vessel. The left femoral vein was subsequently resected, and the excised venous tissue also grew<jats:italic>T. asahii<\/jats:italic>. The patient was successfully treated with voriconazole based on antifungal susceptibilities. This case describes an invasive fungal infection in the absence of typical immunosuppressive conditions commonly associated with<jats:italic>Trichosporon<\/jats:italic>spp. It also illustrates the role of a combination of antimicrobial and surgical management in achieving cure.<\/jats:p>","DOI":"10.1136\/bcr-2017-221441","type":"journal-article","created":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T13:05:19Z","timestamp":1515243919000},"page":"bcr-2017-221441","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Trichosporon asahii<\/i>septic thrombophlebitis following lower extremity amputation in an immunocompetent host"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-7982","authenticated-orcid":false,"given":"Pradeep Kumar","family":"Mada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-1278","authenticated-orcid":false,"given":"Folusakin","family":"Ayoade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,1,6]]},"reference":[{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.1","first-page":"79","article-title":"Infections due to Trichosporon species: new concepts in mycology, pathogenesis, diagnosis and treatment","volume":"5","author":"Walsh","year":"1993","journal-title":"Curr Top Med Mycol"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00003-11"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00713937"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1128\/CMR.9.4.469","article-title":"Virulence factors of medically important fungi","volume":"9","author":"Hogan","year":"1996","journal-title":"Clin Microbiol Rev"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00556-06"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.6","first-page":"106","article-title":"Trichosporon funguemia in a pediatric patient with acute lymphoblastic leukemia","volume":"2","author":"Luke","year":"2015","journal-title":"Elsevier"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.7","first-page":"30","article-title":"Invasive trichosporonmucoides infection in a uremic patient with type 2 diabetes mellitus on maintenance hemodialysis","volume":"25","author":"Jong","year":"2011","journal-title":"ActaNephrologica"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.8","first-page":"577","article-title":"Disseminated trichosporonosis with trichosporon asahii","volume":"9","author":"Takamura","year":"1999","journal-title":"Eur J Dermatol"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.9","doi-asserted-by":"publisher","DOI":"10.1086\/599614"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.10","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.31065"},{"key":"2025042702250103000_2018.jan06_1.bcr-2017-221441.11","doi-asserted-by":"crossref","unstructured":"Zhang E , Sugita T , Tsuboi R , et al . 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