{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:57:53Z","timestamp":1773763073553,"version":"3.50.1"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,9,19]]},"abstract":"<jats:p>Although thrombocytopenia is known to be associated with pathogenesis of retinopathy of prematurity (ROP), immune thrombocytopenic purpura (ITP) is rare in infancy and not reported to occur with ROP. A preterm infant with aggressive posterior ROP developed bilateral massive subconjunctival haemorrhage after scleral indentation during screening. On evaluation, the infant was found to have severe ITP. Following intravenous transfusion of platelets and immunoglobulin, platelet counts improved and subconjunctival haemorrhage resolved over time. This case highlights the unusual presentation of ITP and also discusses the association of thrombocytopenia with ROP. Ophthalmologists should get prompt haematological work-up of such occurrences.<\/jats:p>","DOI":"10.1136\/bcr-2017-221444","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T11:25:52Z","timestamp":1507116352000},"page":"bcr-2017-221444","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Bilateral large subconjunctival haemorrhages unmasking immune thrombocytopenic purpura during retinopathy of prematurity screening"],"prefix":"10.1136","volume":"2017","author":[{"given":"Parijat","family":"Chandra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devesh","family":"Kumawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchir","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jaapos.2011.07.014","article-title":"Widespread retinal hemorrhages after retinopathy of prematurity screening with scleral depression","volume":"15","author":"Jensen","year":"2011","journal-title":"J Aapos"},{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.03.005"},{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.3","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3341\/jkos.2013.54.11.1788","article-title":"Thrombocytopenia after intravitreal bevacizumab injection for macular edema in branch retinal vein occlusion","volume":"54","author":"Lee","year":"2013","journal-title":"J Korean Ophthalmol Soc"},{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.4","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.jaapos.2011.01.015","article-title":"Thrombocytopenia and retinopathy of prematurity","volume":"15","author":"Jensen","year":"2011","journal-title":"J Aapos"},{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-113837"},{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.6","first-page":"124","article-title":"[Idiopathic thrombocytopenic purpura in infants and small children (1 to 3 years old)]","volume":"103","author":"Go\u0163ia","year":"1999","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1600-0609.2006.00714.x","article-title":"Acute immune thrombocytopenic purpura in infants: associated factors, clinical features, treatment and long-term outcome","volume":"77","author":"Wang","year":"2006","journal-title":"Eur J Haematol"},{"key":"2025042712461834000_2017.oct03_1.bcr-2017-221444.8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0021-5155(03)00017-0","article-title":"Subconjunctival hemorrhage: the first presenting clinical feature of idiopathic thrombocytopenic purpura","volume":"47","author":"Sodhi","year":"2003","journal-title":"Jpn J Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T19:46:23Z","timestamp":1745783183000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,4]]},"references-count":8,"alternative-id":["10.1136\/bcr-2017-221444"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221444","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,4]]}}}