{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:25:45Z","timestamp":1745990745533,"version":"3.40.4"},"reference-count":28,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,12,31]]},"abstract":"<jats:p>We present two 11-year-old girls with chronic recurrent multifocal osteomyelitis, treated with adalimumab. Both developed severe intracranial complications to sinusitis. Patient 1 had been treated with adalimumab for 15 months when she developed acute sinusitis complicated by an orbital abscess, forehead swelling, a subdural empyema and osteomyelitis of the frontal bone. She was treated with a rhinosurgical and neurosurgical approach with intravenous antibiotics.Patient 2 had been in adalimumab treatment for 10 weeks. Adalimumab was discontinued 8\u2009weeks prior to developing subdural empyema and subcortical abscesses in combination with sinusitis. She was treated with endoscopic sinus surgery and intravenous antibiotics. Both patients had developed psoriasis and episodes of infection during treatment. They were non-septic and had low fever on presentation. None of the patients suffered any long-term neurological sequelae. The immunosuppressive treatment with adalimumab is considered to be the cause of the sinogenic intracranial complications in our cases.<\/jats:p>","DOI":"10.1136\/bcr-2017-221449","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T05:40:11Z","timestamp":1516254011000},"page":"bcr-2017-221449","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Sinogenic intracranial complications: is adalimumab a culprit?"],"prefix":"10.1136","volume":"2018","author":[{"given":"Mikkel Seremet","family":"Kofoed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Fisker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Estmann","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0593-6302","authenticated-orcid":false,"given":"Anette Dr\u00f8hse","family":"Kjeldsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24492"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.9.969"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.3","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200202000-00005"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1292-x"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.19.2275"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.12.012"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-012-2544-6"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.8","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/art.39013","article-title":"A large national cohort of French patients with chronic recurrent multifocal osteitis","volume":"67","author":"Wipff","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12969-015-0058-0","article-title":"Unusual onset of a case of chronic recurrent multifocal osteomyelitis","volume":"13","author":"Barrani","year":"2015","journal-title":"Pediatr Rheumatol Online J"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.10","first-page":"493","article-title":"Skull involvement in a pediatric case of chronic recurrent multifocal osteomyelitis","volume":"77","author":"Watanabe","year":"2015","journal-title":"Nagoya J Med Sci"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ijporl.2016.05.009","article-title":"Systematic review and case report: Intracranial complications of pediatric sinusitis","volume":"86","author":"Patel","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.12","doi-asserted-by":"publisher","DOI":"10.3171\/2011.3.PEDS10504"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.13","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182748d6e"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jacr.2013.01.001","article-title":"ACR appropriateness criteria sinonasal disease","volume":"10","author":"Cornelius","year":"2013","journal-title":"J Am Coll Radiol"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s13244-015-0424-y","article-title":"Imaging findings of the orbital and intracranial complications of acute bacterial rhinosinusitis","volume":"6","author":"Dankbaar","year":"2015","journal-title":"Insights Imaging"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1035-8"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.17","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200401000-00011"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.18","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ijporl.2015.03.020","article-title":"Management and outcomes in children with sinogenic intracranial abscesses","volume":"79","author":"Patel","year":"2015","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.19","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.ijporl.2015.08.007","article-title":"Pediatric sinogenic epidural and subdural empyema: The role of endoscopic sinus surgery","volume":"79","author":"Garin","year":"2015","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2008.09.009"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jamaoto.2013.1369","article-title":"The significance of Streptococcus anginosus group in intracranial complications of pediatric rhinosinusitis","volume":"139","author":"Deutschmann","year":"2013","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.22","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1055-7"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.23","unstructured":"Furst DE , Fau WR , Fau BM , et al . Tumor necrosis factor antagonists: different kinetics and\/or mechanisms of action may explain differences in the risk for developing granulomatous infection:0049\u2013172."},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.24","unstructured":"European Medicines Agency. Summary of Product Characteristics. 2017 http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/medicines\/human\/medicines\/000481\/human_med_000822.jsp&mid=WC0b01ac058001d124"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.25","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2016-000395"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.26","unstructured":"Tanaka Y , Yamanaka H , Ishiguro N , et al . Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study:1478\u20136362."},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.27","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s10067-008-0948-3","article-title":"Sinusitis: a possible link with adalimumab","volume":"27","author":"Haroon","year":"2008","journal-title":"Clin Rheumatol"},{"key":"2025042702324270000_2018.jan17_1.bcr-2017-221449.28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/lary.24881","article-title":"Prevalence of sinonasal disease in children with Juvenile idiopathic arthritis","volume":"125","author":"Pipolo","year":"2015","journal-title":"Laryngoscope"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:32:52Z","timestamp":1745746372000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,17]]},"references-count":28,"alternative-id":["10.1136\/bcr-2017-221449"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221449","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,1,17]]}}}