{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:10:02Z","timestamp":1756372202341,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,9,22]]},"abstract":"<jats:p>A previously healthy 44-year-old woman presented with 3\u2009days of worsening petechial rash, epistaxis and fatigue. Admission labs revealed pancytopenia, low reticulocyte index and elevated liver enzymes. Bone marrow biopsy demonstrated a profoundly hypocellular bone marrow without dysplasia and additional testing demonstrated an acute hepatitis B infection. In the context of an acute hepatitis B infection, elevated liver enzymes and aplastic anaemia, our patient was diagnosed with severe hepatitis-associated aplastic anaemia due to an acute hepatitis B infection. She was initiated on antiviral therapy with tenofovir and briefly received immunosuppressive therapy with a robust sustained improvement in her blood counts. Acute hepatitis B-associated aplastic anaemia is an exceptionally rare presentation of aplastic anaemia. We present acute hepatitis B-associated aplastic anaemia that resolved with antiviral therapy, which to our knowledge is the second such case reported in the literature and the first using tenofovir.<\/jats:p>","DOI":"10.1136\/bcr-2017-221503","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T06:05:19Z","timestamp":1507010719000},"page":"bcr-2017-221503","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Resolution of acute hepatitis B-associated aplastic anaemia with antiviral therapy"],"prefix":"10.1136","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-7864","authenticated-orcid":false,"given":"Nicholas","family":"Hendren","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern, Dallas, Texas, 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