{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:11:09Z","timestamp":1789726269846,"version":"4.0.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,8,16]]},"abstract":"<jats:p>Non-vitamin K oral anticoagulants (NOACs) are being increasingly prescribed. These drugs act rapidly, have predictable dose-related anticoagulation effect and require no routine laboratory monitoring, making them attractive for both patients and healthcare providers. All NOACs are at least partially excreted thought the kidneys. Renal injury related to NOAC use is being increasingly reported. NOAC-related acute interstitial nephritis (AIN) has only been reported once and that was in context of dabigatran use. We describe the first case of apixaban-related AIN. This case adds an important differential diagnoses that should be considered for any patient presenting with renal injury while being treated with NOACs.<\/jats:p>","DOI":"10.1136\/bcr-2017-221641","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T11:15:18Z","timestamp":1503918918000},"page":"bcr-2017-221641","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Novel oral anticoagulant and kidney injury: apixaban-related acute interstitial nephritis"],"prefix":"10.1136","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-6612","authenticated-orcid":false,"given":"Basma","family":"Abdulhadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi","family":"Mulki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janani","family":"Rangaswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.023143"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/jth.13229","article-title":"Anticoagulation-related nephropathy","volume":"14","author":"Wheeler","year":"2016","journal-title":"J Thromb Haemost"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/298261","article-title":"Dabigatran-related nephropathy in a patient with undiagnosed IgA nephropathy","volume":"2015","author":"Escoli","year":"2015","journal-title":"Case Rep Nephrol"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.4","unstructured":"Basetty P , Bellovich K . A cautionary tale: Dabigatran toxicity associated with allergic interstitial nephritis. American Journal of Kidney Disease. Philadelphia, PA 19103-2899 USA.: WB Saunders Co-Elsevier INC 1600 John F Kennedt Boulevard, STE 1800, 2013."},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.05.044"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.05.013"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.krcp.2014.11.001","article-title":"Anticoagulants and acute kidney injury: clinical and pathology considerations","volume":"33","author":"Brodsky","year":"2014","journal-title":"Kidney Res Clin Pract"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.09.046"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196812052792302"},{"key":"2025042712343393000_2017.aug26_1.bcr-2017-221641.10","first-page":"2527","article-title":"Diagnosis and management of acute interstitial nephritis","volume":"67","author":"Kodner","year":"2003","journal-title":"Am Fam Physician"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T19:34:45Z","timestamp":1745782485000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,28]]},"references-count":10,"alternative-id":["10.1136\/bcr-2017-221641"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221641","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,28]]}}}