{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:26:31Z","timestamp":1787765191120,"version":"build-2784847793"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,8,5]]},"abstract":"<jats:p>Primary adrenal myelolipomas, relatively rare benign tumours of the adrenal cortex are typically unilateral, hormonally inactive and asymptomatic, hence often diagnosed as \u2018adrenal incidentaloma\u2019. Bilateral adrenal myelolipomas, in particular, may be associated with underlying endocrinopathies associated with elevated circulating adrenocorticotropic hormone (ACTH) concentration. Subclinical cortisol hypersecretion, irrespective of its ACTH dependency, does not manifest typical clinical phenotype of hypercortisolemia, and thus termed subclinical Cushing\u2019s syndrome. In this article, hormonal evaluation in a middle-aged woman with diabetes, hypertension and incidentally discovered unilateral adrenal myelolipoma revealed underlying subclinical Cushing\u2019s disease. Abdominal CT revealed another tiny focus in the contralateral adrenal gland, probably representing incipient myelolipoma.<\/jats:p>","DOI":"10.1136\/bcr-2017-221674","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T07:39:24Z","timestamp":1502869164000},"page":"bcr-2017-221674","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Adrenal myelolipoma(s) as presenting manifestation of subclinical Cushing\u2019s disease (eutopic ACTH-dependent Cushing\u2019s syndrome)"],"prefix":"10.1136","volume":"2017","author":[{"given":"Partha Pratim","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Medicine, Midnapore Medical College and Hospital, Midnapore, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjan","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Midnapore Medical College and Hospital, Midnapore, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugata Narayan","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Midnapore Medical College and Hospital, Midnapore, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, IPGME&R\/SSKM Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.1","first-page":"487","article-title":"Myelolipoma in the adrenal cortex; myeloadipose structures","volume":"34","author":"Plaut","year":"1958","journal-title":"Am J Pathol"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.2","doi-asserted-by":"publisher","DOI":"10.1177\/003693307101601206"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.3","first-page":"211","article-title":"Hormonally induced transformation of adrenal into myeloid tissue","volume":"26","author":"Selye","year":"1950","journal-title":"Am J Pathol"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.4","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.41.461"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.5","first-page":"7","article-title":"Ectopic ACTH and adrenal myelolipoma","volume":"53","author":"Sieber","year":"1989","journal-title":"Conn Med"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1472-6823-14-42","article-title":"Increased expression of ACTH (MC2R) and androgen (AR) receptors in giant bilateral myelolipomas from patients with congenital adrenal hyperplasia","volume":"14","author":"Almeida","year":"2014","journal-title":"BMC Endocr Disord"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.7","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-008-9034-2"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-030014"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.9","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7547"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215245"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.14310\/horm.2002.1506","article-title":"Subclinical Cushing's syndrome: current concepts and trends","volume":"13","author":"Zografos","year":"2014","journal-title":"Hormones"},{"key":"2025082623595967000_2017.aug16_1.bcr-2017-221674.12","first-page":"735","article-title":"Subclinical Cushing's syndrome due to adrenal myelolipoma","volume":"121","author":"Boronat","year":"1997","journal-title":"Arch Pathol Lab Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:00:09Z","timestamp":1756278009000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":12,"alternative-id":["10.1136\/bcr-2017-221674"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221674","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]}}}