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After 6 months, imiquimod was discontinued and the patient continued to be treated with quarterly photodynamic therapy. Treatment resulted in significant improvement in the appearance of the lesion, and pathology revealed no evidence of residual disease. The patient has had no clinical signs of disease for &gt;5 years. We conclude that topical imiquimod 5% cream and photodynamic therapy may aid in the treatment of some patients with EMPD.<\/jats:p>","DOI":"10.1136\/bcr-2017-221696","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T09:15:20Z","timestamp":1520241320000},"page":"bcr-2017-221696","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Extramammary Paget\u2019s disease of the scrotum with complete response to imiquimod and photodynamic therapy"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-4233","authenticated-orcid":false,"given":"Tyler M","family":"Bauman","sequence":"first","affiliation":[{"name":"Division of Dermatology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana S","family":"Rosman","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Sheinbein","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Washington University in St Louis School of Medicine, St Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/00007611-200007000-00016","article-title":"Extramammary Paget\u2019s disease","volume":"93","author":"Mehta","year":"2000","journal-title":"South Med J"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.2","first-page":"195","article-title":"Extramammary Paget\u2019s disease: diagnosis and disease pattern","volume":"50","author":"Chaudhuri","year":"1992","journal-title":"Cutis"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.3","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126584"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910215)67:4<933::AID-CNCR2820670413>3.0.CO;2-3"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03242.x"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1365-2230.28.s1.12.x","article-title":"Successful treatment of extramammary Paget\u2019s disease of the scrotum with imiquimod 5% cream","volume":"28(Suppl 1)","author":"Berman","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5070\/D36CD2F48F","article-title":"Treatment of limited extent extramammary Paget\u2019s disease with 5 percent imiquimod cream","volume":"12","author":"Badgwell","year":"2006","journal-title":"Dermatol Online J"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(99)00033-9"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5070\/D34VW339W4","article-title":"Imiquimod 5 percent cream and the treatment of cutaneous malignancy","volume":"10","author":"Navi","year":"2004","journal-title":"Dermatol Online J"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ygyno.2015.07.097","article-title":"Effects of imiquimod on vulvar Paget\u2019s disease: a systematic review of literature","volume":"139","author":"Machida","year":"2015","journal-title":"Gynecol Oncol"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01344.x"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.12","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000209223.68763.b1"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pdpdt.2014.03.006","article-title":"Complete remission of two patients with recurrent and wide spread extramammary Paget disease obtained from 5-aminolevulinic acid-based photodynamic therapy and imiquimod combination treatment","volume":"11","author":"Jing","year":"2014","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"2025082707290380000_2018.mar05_1.bcr-2017-221696.14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00000372-198908000-00004","article-title":"Histogenesis of extramammary and mammary Paget cells. 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