{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:35:44Z","timestamp":1761863744896,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,9,15]]},"abstract":"<jats:p>A 38-year-old man presented with excessive height gain and progressive enlargement of the extremities since childhood. This was compounded by lower limb deformities over the past 5 years. On examination, his height was 196\u2009cm, he had macroglossia, acral enlargement, seborrhoea, hyperhidrosis\u2014suggesting acrogigantism. He had facial asymmetry, wind-swept deformity of lower limbs and a caf\u00e9-au-lait macule over his trunk. Investigations revealed normal-sized pituitary gland with dysplastic cranial bones. Isotope bone scintigraphy was suggestive of polyostotic fibrous dysplasia. A diagnosis of McCune-Albright syndrome was made and trans-sphenoidal hypophysectomy was undertaken. He had persistent hypophosphataemia. Tubular reabsorption of phosphate adjusted for glomerular filtration rate was low and serum FGF-23 level was high. Ga-DOTATATE scintigraphy showed somatostatin-receptor expression in all the dysplastic lesions. FGF-23 produced by the bony lesions could counteract the phosphate-retaining effect of GH excess resulting in hypophosphataemia, which further worsened following hypophysectomy.<\/jats:p>","DOI":"10.1136\/bcr-2017-221827","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:45:30Z","timestamp":1506645930000},"page":"bcr-2017-221827","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Acromegaly with hypophosphataemia: McCune-Albright syndrome"],"prefix":"10.1136","volume":"2017","author":[{"given":"Rimesh","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinaki","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan Kumar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s40618-017-0657-3","article-title":"Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients","volume":"40","author":"Yalin","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJM193704292161701","article-title":"Syndrome characterized by osteitis fibrosa disseminata, areas of pigmentation and endocrine dysfunction, with precocious puberty in females","volume":"216","author":"Albright","year":"1937","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.3","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1750-1172-7-S1-S4","article-title":"McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia","volume":"7 Suppl 1","author":"Collins","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.4","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-3-12"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3826"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.6","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/0140-6736(91)91542-3","article-title":"Juvenile gigantism plus polyostotic fibrous dysplasia in the Tegernsee giant","volume":"338","author":"Nerlich","year":"1991","journal-title":"Lancet"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.7","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0715"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318399"},{"key":"2025082802453522000_2017.sep28_1.bcr-2017-221827.9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11914-016-0317-0","article-title":"Fibrous dysplasia\/McCune-Albright syndrome: clinical and translational perspectives","volume":"14","author":"Robinson","year":"2016","journal-title":"Curr Osteoporos Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:45:43Z","timestamp":1756374343000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":9,"alternative-id":["10.1136\/bcr-2017-221827"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221827","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,9,28]]}}}