{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:40:06Z","timestamp":1756287606986,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,3,14]]},"abstract":"<jats:p>We present a 30+2-weeks-old (30 weeks and 2 days) male, twin 1, born by emergency caesarean section due to twin-twin transfusion syndrome (absent end-diastolic flow and cardiac anomaly in twin 2) presenting with hypertensive crisis on day 3. He was already on milrinone and propranolol. His echocardiogram showed poor left ventricular contractility and after cardiology consultation received sodium nitroprusside, which eventually saved his life by decreasing his blood pressure and improving cardiac function. As sodium nitroprusside is very rarely used for hypertensive crisis in neonates, we would like to share our experiences on dosage, challenges in administration due to its fast onset of action, criteria for monitoring for complications and finally weaning. Baby developed severe bilateral periventricular leukomalacia as a potential complication of hypertensive crisis, preceded by bilateral periventricular flare secondary to twin-twin transfusion.<\/jats:p>","DOI":"10.1136\/bcr-2017-221856","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T09:51:08Z","timestamp":1522230668000},"page":"bcr-2017-221856","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Sodium nitroprusside, a lifesaving treatment for neonatal hypertension: an Irish experience"],"prefix":"10.1136","volume":"2018","author":[{"given":"Alina Gina","family":"Deliu","sequence":"first","affiliation":[{"name":"Department of Neonatology, Rotunda Hospital, Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phani Bhushan Jeerigehalli","family":"Sanneerappa","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Letterkenny University Hospital, Letterkenny, Donegal, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orla","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Our Lady\u2019s Children\u2019s Hospital, Crumlin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Letshwiti","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Rotunda Hospital, Dublin, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0603-2"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2011.08.001"},{"issue":"Suppl 1","key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.3","first-page":"S39","article-title":"Managing hypertension in the newborn infants","volume":"5","author":"Nickavar","year":"2014","journal-title":"Int J Prev Med"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.074"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1755-z"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5830\/CVJA-2013-003","article-title":"Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues","volume":"24","author":"Louw","year":"2013","journal-title":"Cardiovasc J Afr"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.7","doi-asserted-by":"crossref","first-page":"e341","DOI":"10.1002\/phar.1495","article-title":"Minoxidil-associated anorexia in an infant with refractory hypertension","volume":"34","author":"Vesoulis","year":"2014","journal-title":"Pharmacotherapy"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.8","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051287"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.9","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C366"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.10","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197604000-00013"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80477-7"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.12","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903081717"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4103\/0970-9185.142799","article-title":"Sodium nitroprusside in 2014: A clinical concepts review","volume":"30","author":"Hottinger","year":"2014","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"2025082702221853000_2018.mar28_1.bcr-2017-221856.14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00003246-199303000-00027","article-title":"Use of vitamin B12 in the treatment and prevention of nitroprusside-induced cyanide toxicity","volume":"21","author":"Zerbe","year":"1993","journal-title":"Crit Care Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-221856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:22:27Z","timestamp":1756286547000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-221856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,28]]},"references-count":14,"alternative-id":["10.1136\/bcr-2017-221856"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-221856","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,3,28]]}}}