{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:13:42Z","timestamp":1756383222981,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,1,7]]},"abstract":"<jats:p>Eight-and-a-half syndrome is a rare condition that is described as a combination of one-and-a-half syndrome and an ipsilateral facial nucleus lesion. We present a clinical case of occurrence of eight-and-a-half syndrome that was caused by a demyelinating lesion in the dorsal pontine tegmentum. A 44-year-old man presented to the hospital with a subacute onset of horizontal diplopia and left-sided facial weakness. MRI revealed a T2 hyperintense lesion in his dorsal pons, which was consistent with a demyelinating pathology. Treatment with intravenous steroids showed significant improvement in his symptoms. In our case, it occurred due to a suspected demyelinating lesion that was this patient\u2019s first and only demyelinating event, leaving him with a diagnosis of clinically isolated syndrome. His responsiveness to steroids represents the first case report of an adult patient presenting with an eight-and-a-half syndrome secondary to a suspected demyelinating pathology.<\/jats:p>","DOI":"10.1136\/bcr-2017-222057","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T10:48:00Z","timestamp":1517568480000},"page":"bcr-2017-222057","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Rare occurrence of eight-and-a-half syndrome as a clinically isolated syndrome"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1941-1075","authenticated-orcid":false,"given":"Sneha","family":"Jacob","sequence":"first","affiliation":[{"name":"Department of Neurology, West Virginia University Health Sciences Center, Morgantown, West Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Neurology, West Virginia University Health Sciences Center, Morgantown, West Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.1","first-page":"549","volume-title":"Neuroanatomy through clincal cases","volume":"13","author":"Blumenfeld","year":"2002"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.30.5.383"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00041327-199806000-00008","article-title":"Eight-and-a-half syndrome: one-and-a-half syndrome plus cranial nerve VII palsy","volume":"18","author":"Eggenberger","year":"1998","journal-title":"J Neuroophthalmol"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.4","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcr187"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2005.11.003"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.6","doi-asserted-by":"crossref","first-page":"e637","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.01.018","article-title":"Eight and a half syndrome with hemiparesis and hemihypesthesia: the nine syndrome?","volume":"22","author":"Rosini","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.7","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2185"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.8","unstructured":"Raina R , Kaushik M , Mahajan S , et al . A case of multiple sclerosis presenting as eight and half syndrome. Online Journal of Health and Allied Sciences 2013;411."},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.9","doi-asserted-by":"crossref","unstructured":"Kami\u015fli \u00d6 , Tecelli\u0307o\u011flu M , \u00d6zcan A . A case of multiple sclerosis presenting as eight and half syndrome. 17: K\u0131r\u0131kkale \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi, 2015.","DOI":"10.24938\/kutfd.124928"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jaapos.2014.05.007","article-title":"Eight-and-a-half syndrome as presenting sign of childhood multiple sclerosis","volume":"18","author":"Mortzos","year":"2014","journal-title":"J Aapos"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000259422.44235.a8"},{"key":"2025082722500659000_2018.jan26_1.bcr-2017-222057.12","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.3.495"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:50:12Z","timestamp":1756360212000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,26]]},"references-count":12,"alternative-id":["10.1136\/bcr-2017-222057"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222057","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,1,26]]}}}