{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:24:41Z","timestamp":1792196681667,"version":"4.4.0"},"reference-count":17,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,1,23]]},"abstract":"<jats:p>We report the case of two patients with newly diagnosed primary hyperparathyroidism: a 40-year-old woman during pregnancy and a 60-year-old man with initial hypercalcaemic crisis. In the first case, a bilateral neck exploration with parathyroidectomy during the second trimester of pregnancy was unsuccessful and the patient remained hypercalcaemic. Postpartum imaging assessment with technetium (<jats:sup>99m<\/jats:sup>Tc)-sestamibi scintigraphy could not supply conclusive diagnostic results. The use of <jats:sup>18<\/jats:sup>F-fluorocholine (FCH) positron emission tomography (PET)\/CT provided the accurate localisation of an ectopic parathyroid adenoma in the anterior mediastinum which was successfully resected by a thoracoscopic approach. In the second case, <jats:sup>99m<\/jats:sup>Tc-sestamibi scintigraphy was inconclusive as well and FCH-PET\/CT localised an ectopic parathyroid adenoma in the mediastinum and thus bilateral neck exploration could be spared. Both patients had surgical cure of their disease.<\/jats:p>","DOI":"10.1136\/bcr-2017-222089","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T09:50:59Z","timestamp":1522230659000},"page":"bcr-2017-222089","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Localisation of ectopic mediastinal parathyroid adenoma by 18F-fluorocholine PET\/CT"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2239-2696","authenticated-orcid":false,"given":"Maria","family":"Triantafyllidou","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Clinical Nutrition, Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Strobel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Leiser","sequence":"additional","affiliation":[{"name":"Division of Heart and Thoracic Surgery, Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fischli","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Clinical Nutrition, Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00000658-199204000-00002","article-title":"Primary hyperparathyroidism in the 1990s. Choice of surgical procedures for this disease","volume":"215","author":"Kaplan","year":"1992","journal-title":"Ann Surg"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1773-z"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.3","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.12659\/MSM.890983","article-title":"Reoperations for persistent or recurrent primary hyperparathyroidism: results of a retrospective cohort study at a tertiary referral center","volume":"20","author":"Nawrot","year":"2014","journal-title":"Med Sci Monit"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1417"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2011.02.009"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.6","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1097\/MNM.0000000000000595","article-title":"Fluorine-18 fluorocholine PET-CT localizes hyperparathyroidism in patients with inconclusive conventional imaging: a multicenter study from the Netherlands","volume":"37","author":"Kluijfhout","year":"2016","journal-title":"Nucl Med Commun"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejso.2016.09.016","article-title":"Focused parathyroidectomy without intraoperative parathormone testing is safe after pre-operative localization with 18F-fluorocholine PET\/CT","volume":"43","author":"Hocevar","year":"2017","journal-title":"Eur J Surg Oncol"},{"issue":"Suppl 1","key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.8","first-page":"E2159","article-title":"Detection rate of (99m) Tc-MIBI single photon emission computed tomography (SPECT)\/CT in preoperative planning for patients with primary hyperparathyroidism: a meta-analysis","volume":"38","author":"Treglia","year":"2016","journal-title":"Head Neck"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1148\/radiol.2016160768","article-title":"18F fluorocholine PET\/MR imaging in patients with primary hyperparathyroidism and inconclusive conventional imaging: a prospective pilot study","volume":"284","author":"Kluijfhout","year":"2017","journal-title":"Radiology"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1870-5"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-009-0534-4"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2084"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2821"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2837-0"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.15","doi-asserted-by":"crossref","first-page":"e1701","DOI":"10.1097\/MD.0000000000001701","article-title":"A pilot comparison of 18F-fluorocholine PET\/CT, ultrasonography and 123I\/99mTc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism: influence of thyroid anomalies","volume":"94","author":"Michaud","year":"2015","journal-title":"Medicine"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.16","first-page":"92","article-title":"Pharmacokinetics and radiation dosimetry of 18F-fluorocholine","volume":"43","author":"DeGrado","year":"2002","journal-title":"J Nucl Med"},{"key":"2025082707414921000_2018.mar28_1.bcr-2017-222089.17","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2481071451"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:41:58Z","timestamp":1756305718000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,28]]},"references-count":17,"alternative-id":["10.1136\/bcr-2017-222089"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222089","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,28]]}}}