{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T14:40:15Z","timestamp":1771684815800,"version":"3.50.1"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,5,15]]},"abstract":"<jats:p>Aggressive angiomyxoma (AAM) is a rare mesenchymal myxoid tumour localised to the pelvis and\/or perineum in adult females in reproductive age group. AAM is very rare in males, with &lt;50 cases described in literature, and involves scrotum, spermatic cord and perineum. It is slow growing, with a marked tendency for local recurrence after excision, but without metastatic potential. We present a rare case of a paratesticular AAM in a man aged 53\u2009years. Tumour cells were immunoreactive for desmin, smooth muscle actin (SMA), vimentin, CD34 and were negative for S100. Unlike AAMs in females which express oestrogen receptor (ER) and\/or progesterone receptor (PR) in &gt;90% cases, the tumour cells in our case were negative for ER and PR, suggesting that the hypothesis that these markers play a role in tumour development and pathogenesis, does not apply in males. Androgen receptor positivity was noted in 2%\u20135%\u2009tumour cells.<\/jats:p>","DOI":"10.1136\/bcr-2017-222164","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T03:30:32Z","timestamp":1528083032000},"page":"bcr-2017-222164","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Rare paratesticular aggressive angiomyxoma with negative oestrogen and progesterone receptors in a male patient"],"prefix":"10.1136","volume":"2018","author":[{"given":"Azfar","family":"Neyaz","sequence":"first","affiliation":[{"name":"Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuzhat","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pallavi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"2025082622542610000_2018.jun01_1.bcr-2017-222164.1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198307000-00009"},{"key":"2025082622542610000_2018.jun01_1.bcr-2017-222164.2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1046\/j.1442-2042.2003.00716.x","article-title":"Aggressive angiomyxoma in the scrotum expressing androgen and progesterone receptors","volume":"10","author":"Chihara","year":"2003","journal-title":"Int J Urol"},{"key":"2025082622542610000_2018.jun01_1.bcr-2017-222164.3","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/00000478-199211000-00004","article-title":"Aggressive angiomyxoma. 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