{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:31:38Z","timestamp":1790836298449,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,10,20]]},"abstract":"<jats:p>Patients with severe alcoholic hepatitis (SAH) have high mortality in the presence of steroid unresponsiveness in the absence of clear treatment recommendations. Liver transplantation is the curative option in such cases but is controversial in the wake of severe infections, post-transplant recidivism and long waiting on deceased donor listing. Animal and human studies have shed light on the beneficial effects of gut microbiota modulation in alcoholic liver disease. We present the first report of faecal microbiota transplantation (FMT) in a steroid non-responder in whom, clinical, biochemical and liver disease severity scores improved post-FMT and demonstrate distinct bacterial population changes pre-FMT and post-FMT. Healthy donor FMT could be safe and efficacious in SAH not responding to corticosteroid treatment, as a bridge to liver transplantation (LT) or in candidates who are unwilling or not ideal for LT for improvement in short-term transplant free survival. Larger controlled studies are required for confirmation.<\/jats:p>","DOI":"10.1136\/bcr-2017-222310","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T01:45:29Z","timestamp":1510191929000},"page":"bcr-2017-222310","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Healthy donor faecal transplant for corticosteroid non-responsive severe alcoholic hepatitis"],"prefix":"10.1136","volume":"2017","clinical-trial-number":[{"clinical-trial-number":"nct03091010","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Cyriac Abby","family":"Philips","sequence":"first","affiliation":[{"name":"The Liver Unit, Ernakulam Medical Centre, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Phadke","sequence":"additional","affiliation":[{"name":"Molecular, Cellular and Developmental Biology, Genepath Dx, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Biomedical Software and Instrumentation, Helicalbio, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Augustine","sequence":"additional","affiliation":[{"name":"Gastroentrology, Ernakulam Medical Centre, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cld.2012.08.005","article-title":"Diagnosis and management of alcoholic hepatitis","volume":"16","author":"Sohail","year":"2012","journal-title":"Clin Liver Dis"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224097"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.4254\/wjh.v9.i12.567","article-title":"Emerging concepts in alcoholic hepatitis","volume":"9","author":"Fung","year":"2017","journal-title":"World J Hepatol"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.4","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310585"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.5","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jhep.2016.11.008","article-title":"Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice","volume":"66","author":"Ferrere","year":"2017","journal-title":"J Hepatol"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.6","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.cgh.2016.10.029","article-title":"Healthy donor fecal microbiota transplantation in steroid-ineligible severe alcoholic hepatitis: a pilot study","volume":"15","author":"Philips","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22317"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.8","doi-asserted-by":"crossref","unstructured":"Bajaj JS , Kassam Z , Fagan A , et al . Fecal microbiota transplant from a rational stool donor improves Hepatic encephalopathy: a randomized clinical trial. Hepatology 2017.doi:10.1002\/hep.29306","DOI":"10.1002\/hep.29306"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.9","first-page":"706A","article-title":"Fecal microbiota transplantation (FMT) improves outcome and survival in steroid ineligible severe alcoholic hepatitis\u2013A randomized control trial (NCT 02458079)","volume":"64","author":"Philips","year":"2016","journal-title":"Hepatology"},{"key":"2025082800315110000_2017.nov08_1.bcr-2017-222310.10","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8852"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:32:00Z","timestamp":1756366320000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":10,"alternative-id":["10.1136\/bcr-2017-222310"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222310","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,8]]}}}