{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:40:25Z","timestamp":1756370425206,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,10,25]]},"abstract":"<jats:p>A 25-year-old man was seen in outpatient clinic for progressive solid food dysphagia. He was already medicated with a proton pump inhibitor with no improvement. His blood tests showed a slight microcytic anaemia and peripheral eosinophilia. The oesophago-gastro-duodenoscopy showed longitudinal furrows in the distal two-thirds of the oesophagus and a concentric distal stenosis. The biopsies taken showed eosinophilic infiltrates consistent with eosinophilic oesophagitis. There was no improvement with topical fluticasone, so the patient was started on a systemic corticosteroid with resolution of dysphagia and of the oesophageal stenosis. He was kept on topical steroids for symptomatic control. On repeat endoscopy, the duodenal mucosa showed multiple papules that were biopsied. Histology showed features consistent with coeliacdisease. The patient was asymptomatic but there was evidence of iron deficiency anaemia, and so a gluten-free diet was started. Despite only a partial adherence to the diet, the iron deficiency anaemia resolved.<\/jats:p>","DOI":"10.1136\/bcr-2017-222405","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T01:55:26Z","timestamp":1510278926000},"page":"bcr-2017-222405","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic oesophagitis and coeliac disease: is there an association?"],"prefix":"10.1136","volume":"2017","author":[{"given":"Ana Margarida","family":"Vaz","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar do Algarve, Faro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Jesus","family":"Cadilla","sequence":"additional","affiliation":[{"name":"Histopathology Department, Centro Hospitalar do Algarve, Faro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diamantino","family":"Sousa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar do Algarve, Faro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hor\u00e1cio","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar do Algarve, Faro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.06.023"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.60"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/01.mpg.0000243430.32087.5c","article-title":"Cow\u2019s milk protein-induced eosinophilic esophagitis in a child with gluten-sensitive enteropathy","volume":"44","author":"Kagalwalla","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.4","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.71"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02787.x"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/2050640616689525","article-title":"Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults","volume":"5","author":"Lucendo","year":"2017","journal-title":"United European Gastroenterol J"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.8","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26679"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.10","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s10620-010-1383-2","article-title":"Adult patients with eosinophilic esophagitis do not show an increased frequency of the HLA-DQ2\/DQ8 genotypes predisposing to celiac disease","volume":"56","author":"Lucendo","year":"2011","journal-title":"Dig Dis Sci"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.11","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.3390\/nu5093329","article-title":"2013 update on celiac disease and eosinophilic esophagitis","volume":"5","author":"Pellicano","year":"2013","journal-title":"Nutrients"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.12","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(00)80354-0"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03388.x"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.14","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1440-1746.2007.05239.x","article-title":"Eosinophilic esophagitis in children with celiac disease","volume":"23","author":"Ooi","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/MPG.0b013e3181a70af4","article-title":"Celiac disease and eosinophilic esophagitis: a true association","volume":"50","author":"Leslie","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.16","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1097\/MCG.0b013e318221aefd","article-title":"Increased incidence of eosinophilic esophagitis in children and adults with celiac disease","volume":"46","author":"Thompson","year":"2012","journal-title":"J Clin Gastroenterol"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.17","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/dote.12419","article-title":"Co-occurrence of eosinophilic esophagitis and potential\/probable celiac disease in an adult cohort: a possible association with implications for clinical practice","volume":"29","author":"Johnson","year":"2016","journal-title":"Dis Esophagus"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/apt.12859","article-title":"Systematic review: the association between eosinophilic oesophagitis and coeliac disease","volume":"40","author":"Lucendo","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.19","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311944"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ncpgasthep0259","article-title":"Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases","volume":"2","author":"Fasano","year":"2005","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.21","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.117986"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.22","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3109\/00365521.2013.792389","article-title":"Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study","volume":"48","author":"Ludvigsson","year":"2013","journal-title":"Scand J Gastroenterol"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-230X-13-96","article-title":"The association between celiac disease and eosinophilic esophagitis in children and adults","volume":"13","author":"Stewart","year":"2013","journal-title":"BMC Gastroenterol"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13104-015-1256-z","article-title":"Eosinophilic esophagitis associated with celiac disease in children","volume":"8","author":"Dharmaraj","year":"2015","journal-title":"BMC Res Notes"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.25","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.cgh.2015.02.018","article-title":"Increased Risk of Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients With Active Celiac Disease on Biopsy","volume":"13","author":"Jensen","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/MPG.0000000000000642","article-title":"Esophageal eosinophilia in pediatric patients with celiac disease: is it a causal or an incidental association?","volume":"60","author":"Ahmed","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025082801001574000_2017.nov09_1.bcr-2017-222405.27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/MPG.0000000000001499","article-title":"The Association Between Celiac Disease and Eosinophilic Esophagitis: Mayo Experience and Meta-analysis of the Literature","volume":"65","author":"Hommeida","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:00:26Z","timestamp":1756368026000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":27,"alternative-id":["10.1136\/bcr-2017-222405"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222405","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,11,9]]}}}