{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:01:17Z","timestamp":1745812877097,"version":"3.40.4"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,12,25]]},"abstract":"<jats:p>Standardised approaches to functional immune assessment after haematopoietic cell transplantation (HCT) are lacking. A 12-year-old girl with relapsed acute myelogenous leukaemia, 2 years post-unrelated HCT, underwent immunological evaluation prior to receiving live vaccinations. Assessment of standard immune parameters and T-cell proliferation to phytohaemagglutinin was reassuring. She was given<jats:italic>Varicella<\/jats:italic>vaccination based on usual post-transplant protocols but was hospitalised 10 days later with localised<jats:italic>Varicella<\/jats:italic>infection (vaccine strain). Following recovery, she underwent further assessment that showed reduced T-cell proliferation to an anti-CD3 stimulation panel (anti-CD3 alone, soluble anti-CD3<jats:sup>+<\/jats:sup>anti-CD28 and soluble anti-CD3<jats:sup>+<\/jats:sup>plus exogenous IL-2). On reassessment, 7 months later, T-cell responses to anti-CD3 stimulation were normal and she was revaccinated without further incident. Measurement of T-cell proliferation to anti-CD3 stimulants likely yields more useful information about global T-cell function and should be strongly considered prior to live vaccine administration post-allogeneic haematopoietic transplant.<\/jats:p>","DOI":"10.1136\/bcr-2017-222417","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T04:30:12Z","timestamp":1516768212000},"page":"bcr-2017-222417","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Optimal approach to assessing T-cell function in haematopoietic cell transplant recipients"],"prefix":"10.1136","volume":"2018","author":[{"given":"Joshua M","family":"Dorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshini 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