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Serological studies were positive for perinuclear antineutrophil antibodies specific to proteinase-3 antigen, and the patient was ultimately diagnosed with granulomatosis with polyangiitis. Intravenous pulse dose steroids were initiated followed by monthly pulse cyclophosphamide for 6\u2009months, resulting in rapid and significant improvement of the wounds.<\/jats:p>","DOI":"10.1136\/bcr-2017-222491","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T08:37:32Z","timestamp":1517387852000},"page":"bcr-2017-222491","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["When a wound is the harbinger of a serious underlying systemic illness"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8647-5733","authenticated-orcid":false,"given":"Shweta","family":"Kishore","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University of Mississippi Medical Center, Jackson, Mississippi, 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