{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:10:02Z","timestamp":1745748602900,"version":"3.40.4"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,1,9]]},"abstract":"<jats:p>A 14-year-old girl and a 30-year-old woman presented with localised hyperhidrosis on the dorsal hand and wrist, respectively, provoked by different stimuli such as physical activity and minor trauma to the skin. The skin was seemingly normal in both patients where an iodine\u2013starch test revealed a well-demarcated area of hyperhidrosis. Following histopathological examination, the diagnosis was unilateral localised hyperhidrosis in both cases; one with normal histology and one with a nevus sudoriferous. Both patients were successfully treated with botulinum toxin type A. The 30-year-old woman additionally used low-dose propantheline bromide periodically and experienced long-term remission on this therapy. Hyperhidrosis may embarrass and interfere with patients\u2019 school and careers, and it is therefore important to tailor an effective individual treatment.<\/jats:p>","DOI":"10.1136\/bcr-2017-222530","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:35:27Z","timestamp":1517405727000},"page":"bcr-2017-222530","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Two patients with localised hyperhidrosis of the hand based on functional and structural abnormalities of sweat glands"],"prefix":"10.1136","volume":"2018","author":[{"given":"Bj\u00f8rn H","family":"Kristiansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim H","family":"Lindahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine A U","family":"Pallesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anette","family":"Bygum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1046\/j.1525-1470.2000.017004328.x","article-title":"Localized paroxysmal hyperhidrosis","volume":"17","author":"Lorette","year":"2000","journal-title":"Pediatr Dermatol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.2","first-page":"194","article-title":"Naevus sudoriferus","volume":"180","author":"Mestdagh","year":"1990","journal-title":"Dermatologica"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jaad.2003.12.030","article-title":"Eccrine nevus","volume":"51","author":"Kawaoka","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2340\/00015555-0144","article-title":"Mucinous eccrine naevus presenting with hyperhidrosis: a case report","volume":"86","author":"Man","year":"2006","journal-title":"Acta Derm Venereol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1525-1470.2008.00719.x","article-title":"Eccrine nevus presenting as a hypopigmented patch","volume":"25","author":"Salama","year":"2008","journal-title":"Pediatr Dermatol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/00015550252948310","article-title":"Eccrine naevus: case report and literature review","volume":"82","author":"V\u00e1zquez","year":"2002","journal-title":"Acta Derm Venereol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1947.62880070013010"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb07360.x"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1997.tb01080.x"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0190-9622(85)70118-1","article-title":"Episodic hyperhidrosis on the dorsum of hands","volume":"12","author":"Chan","year":"1985","journal-title":"J Am Acad Dermatol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.11","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1967.01610010073012"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1525-1470.2000.01705.x","article-title":"Idiopathic localized unilateral hyperhidrosis in a child","volume":"17","author":"Ghali","year":"2000","journal-title":"Pediatr Dermatol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.13","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1468-3083.2008.02630.x","article-title":"Efficacy of botulinum toxin for a congenital eccrine naevus","volume":"22","author":"Honeyman","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025042702420534000_2018.jan31_1.bcr-2017-222530.14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1001\/archderm.136.4.547-c","article-title":"Grouped papules on the arm of an infant. 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