{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:23:23Z","timestamp":1759778603158,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,3,16]]},"abstract":"<jats:p>An 11-year-old female patient presented with diminution of vision in both the eyes for the last 4\u2009days. She had redness, watering and photophobia for the past 11\u2009days. Slit lamp examination revealed multiple disc-shaped corneal stromal infiltrates with an overlying epithelial defect and hypopyon in both the eyes. A provisional diagnosis of infective keratitis was made. The patient was started on empirical antimicrobial therapy. However, no improvement was noted over the next 72\u2009hours. Microbiological examination of the corneal scraping from both the eyes was negative. Considering the above, provisional diagnosis was changed to immune stromal keratouveitis and the patient was started on topical steroids. Further evaluation revealed a positive Mantoux test (30\u00d720\u2009mm) and contrast enhanced CT chest showing pulmonary nodules, suggestive of tuberculosis. The patient was subsequently started on antitubercular treatment. The infiltrates along with the ulcer and anterior uveitis responded dramatically to the revised treatment and resolved completely within 7\u2009days of therapy.<\/jats:p>","DOI":"10.1136\/bcr-2017-222571","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T07:25:27Z","timestamp":1522913127000},"page":"bcr-2017-222571","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Immune stromal keratitis: a rare ocular presentation of tuberculosis"],"prefix":"10.1136","volume":"2018","author":[{"given":"Deepali","family":"Singhal","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India"},{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prafulla Kumar","family":"Maharana","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"},{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namrata","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"},{"name":"Department of Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"2025082803024865000_2018.apr05_1.bcr-2017-222571.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.08.015"},{"key":"2025082803024865000_2018.apr05_1.bcr-2017-222571.2","first-page":"160","article-title":"Corneal manifestations of tuberculosis: about 2 cases","volume":"4","author":"Sarah","year":"2016","journal-title":"American Journal of Medical Case Reports"},{"key":"2025082803024865000_2018.apr05_1.bcr-2017-222571.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.iio.0000155935.60213.ac"},{"key":"2025082803024865000_2018.apr05_1.bcr-2017-222571.4","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e31827a025e"},{"key":"2025082803024865000_2018.apr05_1.bcr-2017-222571.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.157644"},{"key":"2025082803024865000_2018.apr05_1.bcr-2017-222571.6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4103\/0974-620X.169888","article-title":"Peripheral ulcerative keratitis associated with chronic malabsorption syndrome and miliary tuberculosis in a child","volume":"8","author":"Arora","year":"2015","journal-title":"Oman J Ophthalmol"},{"key":"2025082803024865000_2018.apr05_1.bcr-2017-222571.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(99)00185-9"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:02:54Z","timestamp":1756375374000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,5]]},"references-count":7,"alternative-id":["10.1136\/bcr-2017-222571"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222571","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,4,5]]}}}