{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:15:38Z","timestamp":1776978938044,"version":"3.51.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,1,15]]},"abstract":"<jats:p>Neurofibromatosis type 1 (NF1)-related lung disease is a rare but increasingly recognised, high morbidity associated feature of the condition. We present a 48-year-old male patient with NF1, who was initially admitted for a subarachnoid haemorrhage requiring aneurysmal coil embolisation. During his recovery, he developed a left-sided pneumothorax requiring chest tube placement followed by concerns for re-expansion pulmonary oedema requiring intubation. Subsequently, the patient also developed a right-sided pneumothorax requiring additional chest tube placement but did not develop right-sided pulmonary oedema. During his hospitalisation, the patient also exemplified other important NF1-related pathophysiology including pheochromocytoma, cerebrovascular abnormalities and cardiovascular manifestations. Due to his multiple comorbidities and poor prognosis, we held a goals of care discussion with the patient\u2019s mother, and with her agreement, the patient underwent compassionate withdrawal of artificial life support.<\/jats:p>","DOI":"10.1136\/bcr-2017-222614","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:39:22Z","timestamp":1517405962000},"page":"bcr-2017-222614","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Neurofibromatosis type 1: a case highlighting pulmonary and other rare clinical manifestations"],"prefix":"10.1136","volume":"2018","author":[{"given":"Khoa Anh","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Elnaggar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie M.","family":"Gallant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged","family":"Tanios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2012.12.002"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112313052704"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.3","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.2214\/ajr.173.6.10584812","article-title":"Thoracic manifestations of neurofibromatosis-I","volume":"173","author":"Rossi","year":"1999","journal-title":"AJR Am J Roentgenol"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00044006"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)62480-0"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.6","first-page":"205","article-title":"Reexpansion pulmonary edema","volume":"14","author":"Sohara","year":"2008","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68171-2"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.8","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30475"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.9","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150544.00016.69"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.10","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001113)95:2<108::AID-AJMG4>3.0.CO;2-0"},{"key":"2025042702420044000_2018.jan31_1.bcr-2017-222614.11","doi-asserted-by":"publisher","DOI":"10.4250\/jcu.2011.19.2.76"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:42:08Z","timestamp":1745746928000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":11,"alternative-id":["10.1136\/bcr-2017-222614"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222614","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]}}}