{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:42:53Z","timestamp":1756384973479,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,11,20]]},"abstract":"<jats:p>A 13-\u00bd-year-old boy was referred to the Department of Endocrinology as a case of thyrotoxicosis for initiation of antithyroid medication. His chief complaint was a swelling in front of the neck, which was incidentally noted by his mother 2 weeks prior to presentation. He denied any history of symptoms suggestive of hyperthyroidism or ophthalmological involvement. His physical examination was unremarkable except for a grade 2 goitre. Thyroid function test revealed elevated free triiodothyronine and tetraiodothyronine in the face of an unsuppressed thyroid-stimulating hormone level. Technetium-99 uptake scan showed increased uptake indicating enhanced thyroid activity. However, he was clinically euthyroid. This raised the possibility of resistance to thyroid hormones, which was confirmed by documenting similar thyroid function test abnormalities in other members of his family and genetic testing. The family was reassured of the benign nature of the condition.<\/jats:p>","DOI":"10.1136\/bcr-2017-222712","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T01:25:20Z","timestamp":1511832320000},"page":"bcr-2017-222712","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Puzzling thyroid function test"],"prefix":"10.1136","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9444-1154","authenticated-orcid":false,"given":"Nandhini","family":"Lakshmana Perumal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical Education, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya Prakash","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadishkumar","family":"Kamalanathan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Moran","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Science, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"2025082805252215000_2017.nov26_1.bcr-2017-222712.1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-27-2-279"},{"key":"2025082805252215000_2017.nov26_1.bcr-2017-222712.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-8-199510150-00002"},{"key":"2025082805252215000_2017.nov26_1.bcr-2017-222712.3","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00184-7"},{"key":"2025082805252215000_2017.nov26_1.bcr-2017-222712.4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1089\/thy.1997.7.775","article-title":"Clinical and hormonal outcome after two years of triiodothyroacetic acid treatment in a child with thyroid hormone resistance","volume":"7","author":"Radetti","year":"1997","journal-title":"Thyroid"},{"key":"2025082805252215000_2017.nov26_1.bcr-2017-222712.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7546453","article-title":"Syndrome of reduced sensitivity to thyroid hormones: two case reports and a literature review","volume":"2016","author":"Anyfantakis","year":"2016","journal-title":"Case Rep Endocrinol"},{"key":"2025082805252215000_2017.nov26_1.bcr-2017-222712.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2007.03.005"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:25:27Z","timestamp":1756383927000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":6,"alternative-id":["10.1136\/bcr-2017-222712"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222712","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,11,27]]}}}