{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:12:22Z","timestamp":1773007942435,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,11,7]]},"abstract":"<jats:p>Gas gangrene is a life-threatening, necrotising soft tissue infection. Colorectal malignancy-associated <jats:italic>Clostridiumsepticum<\/jats:italic> is a rare cause of gas gangrene. This case outlines an initial presentation of colonic malignancy as gas gangrene from <jats:italic>C.septicum<\/jats:italic> infection.<\/jats:p>\n               <jats:p>A 69-year-old man presented with abdominal pain, vomiting and constipation. Abdominal X-ray revealed dilated small bowel loops. Lactate was elevated. A diagnosis of small bowel obstruction was made. Subsequent CT revealed caecal thickening and subcutaneous emphysema overlying the left flank. Clinically, he became haemodynamically unstable. Examination revealed crepitus overlying the left flank in keeping with gas gangrene. The patient required immediate surgical debridement. Tissue specimens cultured <jats:italic>C.septicum<\/jats:italic>. Following a complicated postoperative period, he was transferred to the plastic surgery team for further tissue debridement and reconstruction. A colonoscopy was later performed which was suspicious for malignancy. Colorectal multidisciplinary team discussion is awaited.<\/jats:p>","DOI":"10.1136\/bcr-2017-222759","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T07:00:37Z","timestamp":1512198037000},"page":"bcr-2017-222759","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Deadly combination: <i>Clostridium septicum<\/i> and colorectal malignancy"],"prefix":"10.1136","volume":"2017","author":[{"given":"Carolyn","family":"Cullinane","sequence":"first","affiliation":[{"name":"General Surgery, University Hospital Limerick, Dooradoyle, Limerick, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Earley","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Limerick, Dooradoyle, Limerick, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shona","family":"Tormey","sequence":"additional","affiliation":[{"name":"General Surgery, University Hospital Limerick, Limerick, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,12,2]]},"reference":[{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.1","first-page":"57-68","article-title":"Gas gangrene and necrotizing fasciitis in the upper extremity","volume":"13","author":"Perry","year":"2004","journal-title":"J Surg Orthop Adv"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.2","doi-asserted-by":"publisher","DOI":"10.1086\/341928"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80023-6"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03160160021004"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/248453","article-title":"Clostridium septicum sepsis and colon carcinoma: report of 4 cases","volume":"2011","author":"Mao","year":"2011","journal-title":"Case Rep Med"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.6","unstructured":"Wells CL , Wilkins TD . Clostridia: sporeforming anaerobic bacilli. In: Baron S , ed. Medical Microbiology. Galveston (TX): The University of Texas Medical Branch at Galveston, 1996."},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radcr.2016.02.006","article-title":"Massive gas gangrene secondary to occult colon carcinoma","volume":"11","author":"Griffin","year":"2016","journal-title":"Radiol Case Rep"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.8","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.2.286"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.9","doi-asserted-by":"crossref","unstructured":"Nanjappa S , Shah S , Pabbathi S . Case Report: Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis, 2015.","DOI":"10.1155\/2015\/694247"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.10","first-page":"216382","article-title":"Foudroyant course of an extensive Clostridium septicum gas gangrene in a diabetic patient with occult carcinoma of the colon","volume":"2013","author":"Hartel","year":"2013","journal-title":"Case Rep Orthop"},{"key":"2025082701550305000_2017.dec02_1.bcr-2017-222759.11","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1128\/iai.60.3.784-790.1992","article-title":"Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum","volume":"60","author":"Ballard","year":"1992","journal-title":"Infect Immun"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:55:17Z","timestamp":1756284917000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,2]]},"references-count":11,"alternative-id":["10.1136\/bcr-2017-222759"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222759","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,2]]}}}