{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:10:01Z","timestamp":1756303801570,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,2,10]]},"abstract":"<jats:p>Peripheral neurological complications of lymphomas are rare and much less frequent than central complications. Nonetheless, on occasion, systemic non-Hodgkin\u2019s lymphoma may directly infiltrate the peripheral nervous system at various levels. This report describes a man with non-Hodgkin\u2019s lymphoma and leptomeningeal disease who developed progressive areflexic quadraparesis. Initial electromyography (EMG) was consistent with a polyradiculopathy and a repeat EMG performed 1\u2009month later for worsening symptoms showed evidence of demyelination. The patient expired due to systemic complications of his illness. Autopsy of the sural nerve showed moderately severe distal sensory axonal loss, direct infiltration of the brachial plexus by malignant lymphocytes and demyelination in brachial and lumbar plexus, most prominent in areas of neoplastic infiltration. Based on this patient\u2019s course and pathology, we suggest that widespread demyelination may accompany neurolymphomatosis and the clinical presentation may be indistinguishable from an acute demyelinating neuropathy.<\/jats:p>","DOI":"10.1136\/bcr-2017-222814","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T09:15:25Z","timestamp":1520241325000},"page":"bcr-2017-222814","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Acute demyelinating neuropathy in a patient with neurolymphomatosis"],"prefix":"10.1136","volume":"2018","author":[{"given":"Rola A","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of Neurology, UMKC School of Medicine Saint Luke\u2019s Hospital, Kansas City, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-9320","authenticated-orcid":false,"given":"Charles 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