{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:41:53Z","timestamp":1781322113242,"version":"3.54.1"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,1,27]]},"abstract":"<jats:p>An 82-year-old Caucasian woman with a history of basal cell carcinoma on vismodegib presented with nausea, vomiting and intermittent abdominal pain. Laboratory results were remarkable for the elevation of liver enzymes. Endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiogram (PTC) did not show evidence of intrahepatic or extrahepatic obstruction of the biliary tract. During PTC external biliary catheter was placed; however, bilirubin continued to rise. Further, laboratory work-up and imaging studies ruled out other possible aetiologies for hepatotoxicity such as infections, autoimmune hepatitis and other drugs known to be hepatotoxic thus leaving vismodegib the most likely cause of hepatotoxicity.<\/jats:p>","DOI":"10.1136\/bcr-2017-222969","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T13:50:14Z","timestamp":1518097814000},"page":"bcr-2017-222969","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Hepatotoxicity Associated With Vismodegib"],"prefix":"10.1136","volume":"2018","author":[{"given":"Prabhjot S","family":"Bedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-033X","authenticated-orcid":false,"given":"Manoj P","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Tageja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Laird-Fick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013506696"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2012.08.011"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/0976-500X.107628","article-title":"The dawn of hedgehog inhibitors: Vismodegib","volume":"4","author":"Sandhiya","year":"2013","journal-title":"J Pharmacol Pharmacother"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1517\/14740338.2014.939952","article-title":"Efficacy and safety of vismodegib : a new therapeutic agent in the treatment of basal cell carcinoma","volume":"13","author":"Lyons","year":"2014","journal-title":"Expert Opin Drug Saf"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s12885-017-3286-5","article-title":"Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study","volume":"17","author":"Sekulic","year":"2017","journal-title":"BMC Cancer"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.023"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s40268-016-0168-2","article-title":"Hepatotoxicity with Vismodegib: An MD Anderson Cancer Center and Research on Adverse Drug Events and Reports Project","volume":"17","author":"Edwards","year":"2017","journal-title":"Drugs R D"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.8","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12543"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.9","unstructured":"United States National Library of Medicine. Search Livertox Database [Internet]. https:\/\/livertox.nlm.nih.gov (cited 2017 Sep 16)."},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052270"},{"key":"2025042702494306000_2018.feb08_1.bcr-2017-222969.11","unstructured":"Schwab M , ed. CTCAE. In: Encyclopedia of Cancer. Heidelberg, Berlin: Springer, 2008:778."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-222969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:49:51Z","timestamp":1745747391000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-222969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":11,"alternative-id":["10.1136\/bcr-2017-222969"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-222969","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]}}}