{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:40:05Z","timestamp":1745750405607,"version":"3.40.4"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,2,8]]},"abstract":"<jats:p>The authors report a case of a 15-year-old girl with hypopituitarism due to pituitary stalk interruption syndrome diagnosed in the neonatal period. The patient was admitted to the emergency room with impaired consciousness and hypoglycaemia. The day before, she increased her water intake to about 1.5 L to perform a pelvic ultrasound. In the following hours, she developed vomiting and food refusal. Blood analysis revealed hypoglycaemia, hyponatraemia, decreased serum osmolality and normal urinary density. Hyponatraemia and adrenal crisis were managed with a gradual but slow resolution of consciousness and electrolytic balance. This case describes an episode of iatrogenic water intoxication in a patient under desmopressin treatment. Although uncommon, dilutional hyponatraemia is the main complication of desmopressin treatment. We reinforce the importance of patients and caregivers\u2019 long-life education for the potential complications of an increase in fluid intake in patients treated with desmopressin.<\/jats:p>","DOI":"10.1136\/bcr-2017-223021","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T09:10:30Z","timestamp":1520586630000},"page":"bcr-2017-223021","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Iatrogenic water intoxication in a female adolescent with hypopituitarism"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-1940","authenticated-orcid":false,"given":"Ana Margarida","family":"Monteiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olinda","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.beem.2015.04.013","article-title":"Management of diabetes insipidus and adipsia in the child","volume":"29","author":"Di Iorgi","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2326"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.beem.2016.02.007","article-title":"Diabetes insipidus: differential diagnosis and management","volume":"30","author":"Robertson","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1515\/jpem-2013-0368","article-title":"Management of central diabetes insipidus with oral desmopressin lyophilisate in infants","volume":"27","author":"Korkmaz","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1515\/jpem-2013-0078","article-title":"Desmopressin administration in children with central diabetes insipidus: a retrospective review","volume":"26","author":"Ooi","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.6","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2015-133740"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.7","doi-asserted-by":"crossref","first-page":"e390","DOI":"10.1111\/j.1651-2227.2012.02765.x","article-title":"Too little water or too much: hyponatremia due to excess fluid intake","volume":"101","author":"Miyamoto","year":"2012","journal-title":"Acta Paediatr"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/PEC.0b013e3181e5bf9e","article-title":"Two unusual pediatric cases of dilutional hyponatremia","volume":"26","author":"Boetzkes","year":"2010","journal-title":"Pediatr Emerg Care"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.9","doi-asserted-by":"crossref","first-page":"385.e1","DOI":"10.1016\/j.ajem.2009.01.029","article-title":"Iatrogenic water intoxication after pelvic ultrasonography imaging","volume":"28","author":"Camkurt","year":"2010","journal-title":"Am J Emerg Med"},{"key":"2025042703023521000_2018.mar08_2.bcr-2017-223021.10","first-page":"429","article-title":"Iatrogenic water intoxication during pelvic ultrasonography in a patient with diabetes insipidus","volume":"54","author":"Derin\u00f6z","year":"2012","journal-title":"Turk J Pediatr"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-223021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:02:42Z","timestamp":1745748162000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-223021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":10,"alternative-id":["10.1136\/bcr-2017-223021"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-223021","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,3,9]]}}}