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Histopathological examination of the surgical specimen was indicative of malignant melanoma, and immunohistochemical examination showed positivity to S100 protein, Melan-A, HMB-45 and vimentin. A series of postoperative clinical, laboratory and imaging examinations revealed no suspicious lesions in the skin, eye, leptomeninges or other sites. Therefore, the diagnosis of primary colonic melanoma was confirmed. Only 36 additional cases of primary colonic melanoma have been reported to date. These rare neoplasms are challenging to diagnose and usually require a multidisciplinary treatment approach, including surgery, chemotherapy and possibly immunotherapy or radiotherapy.<\/jats:p>","DOI":"10.1136\/bcr-2017-223282","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T09:10:32Z","timestamp":1520586632000},"page":"bcr-2017-223282","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Primary malignant melanoma of the ascending colon"],"prefix":"10.1136","volume":"2018","author":[{"given":"Spyridon","family":"Miliaras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-6909","authenticated-orcid":false,"given":"Ioannis A","family":"Ziogas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos S","family":"Mylonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios N","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"2025042703020328000_2018.mar08_2.bcr-2017-223282.1","first-page":"739","article-title":"Primary mucosal melanomas: a comprehensive review","volume":"5","author":"Mihajlovic","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"2025042703020328000_2018.mar08_2.bcr-2017-223282.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01604.x"},{"key":"2025042703020328000_2018.mar08_2.bcr-2017-223282.3","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200003000-00014"},{"key":"2025042703020328000_2018.mar08_2.bcr-2017-223282.4","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0417-3"},{"key":"2025042703020328000_2018.mar08_2.bcr-2017-223282.5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1477-7819-9-14","article-title":"Pathogenesis, diagnosis and management of primary melanoma of the colon","volume":"9","author":"Khalid","year":"2011","journal-title":"World J Surg Oncol"},{"key":"2025042703020328000_2018.mar08_2.bcr-2017-223282.6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4318\/tjg.2010.0048","article-title":"primary or metastatic? 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