{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:49:56Z","timestamp":1758631796428,"version":"3.40.4"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,2,18]]},"abstract":"<jats:p><jats:italic>Streptococcus anginosus<\/jats:italic>is a clinically important pathogen that is emerging globally but remains poorly investigated. Here, we report the first case of acute glomerulonephritis resulting from infection with<jats:italic>S. anginosus<\/jats:italic>. Glomerulonephritis is typically caused by<jats:italic>S. pyogenes<\/jats:italic>and reports secondary to other strains including<jats:italic>S. zooepidemicus<\/jats:italic>and<jats:italic>S. constellatus<\/jats:italic>exist. Infection with<jats:italic>S. anginosus<\/jats:italic>in this patient was associated with acute nephritis (haematuria, oedema and hypertension), nephrotic syndrome and progressive azotemia. There was activation of the complement system. The presence of low C1q and elevated anti-C1q binding complexes points to a potential pathogenic role. Testing for streptococcal antigens was strongly positive. Emerging nephritogenic strains of<jats:italic>S. anginosus<\/jats:italic>present a significant health concern for both developed and developing countries.<\/jats:p>","DOI":"10.1136\/bcr-2017-223314","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T14:20:12Z","timestamp":1520605212000},"page":"bcr-2017-223314","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Acute glomerulonephritis secondary to<i>Streptococcus 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