{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:40:50Z","timestamp":1791222050342,"version":"4.1.0"},"reference-count":35,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,3,14]]},"abstract":"<jats:p>Methaemoglobin is a form of haemoglobin in which the ferrous (Fe<jats:sup>2+<\/jats:sup>) ion contained in the iron\u2013porphyrin complex of haem is oxidised to its ferric (Fe<jats:sup>3+<\/jats:sup>) state. Methaemoglobinaemia, the presence of methaemoglobin in the blood, is most commonly treated with methylene blue. However, methylene blue cannot be used in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency as it is ineffective in such patients and it can worsen G6PD deficiency haemolysis. We report the case of a 30-year-old man who presented with clinical features of G6PD deficiency-associated haemolysis and was found to have severe methaemoglobinaemia (35%). He was administered blood transfusions and intravenous ascorbic acid. His methaemoglobinaemia resolved within 24\u2009hours. This case demonstrates the successful management of a patient with severe methaemoglobinaemia in the setting of G6PD deficiency haemolysis. Emergency physicians should be aware of the possible co-occurrence of severe methaemoglobinaemia in a patient with G6PD deficiency haemolysis.<\/jats:p>","DOI":"10.1136\/bcr-2017-223369","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T09:52:55Z","timestamp":1522230775000},"page":"bcr-2017-223369","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Severe acute haemolytic anaemia associated with severe methaemoglobinaemia in a G6PD-deficient man"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-7810","authenticated-orcid":false,"given":"Abdul","family":"Rehman","sequence":"first","affiliation":[{"name":"Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan"},{"name":"Department of Medicine, Hamad Medical Corporation, Doha, 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