{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:00:37Z","timestamp":1775314837894,"version":"3.50.1"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,2,28]]},"abstract":"<jats:p>Case reports have described an association between oral food\/aeroallergen immunotherapy with the development of eosinophilic oesophagitis (EoE). The underlying mechanism of this is poorly understood, as is the role that both food\/aeroallergen sensitisation plays in the pathogenesis of EoE. Specific immunotherapy has a long-standing history of use in the management of moderate\/severe\u2009seasonal allergic rhinitis (AR), caused by tree\/grass pollens. Subcutaneous immunotherapy (SCIT) to grass pollen is less commonly used in children than sublingual immunotherapy (SLIT) or oral immunotherapy for practical reasons. We describe a case of a child with severe grass-pollen related AR and known, but quiescent, EoE, who developed recurrence of oesophageal symptoms on two separate occasions, coincident with the commencement of SLIT to grass pollen. He was subsequently started on SCIT to grass pollen and developed recurrence of symptoms of EoE\u2014a phenomenon that has yet to be reported in the medical literature.<\/jats:p>","DOI":"10.1136\/bcr-2017-223465","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T13:37:06Z","timestamp":1521121026000},"page":"bcr-2017-223465","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Recurrence of eosinophilic oesophagitis with subcutaneous grass pollen immunotherapy"],"prefix":"10.1136","volume":"2018","author":[{"given":"Rosy","family":"Wells","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A T","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Furman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bpg.2015.09.005","article-title":"Clinical features of eosinophilic esophagitis in children and adults","volume":"29","author":"Miehlke","year":"2015","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32813aee4a"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200109841"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)01715-9"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.anai.2015.07.004","article-title":"Seasonal exacerbation of esophageal eosinophilia in children with eosinophilic esophagitis and allergic rhinitis","volume":"115","author":"Ram","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/apt.13273","article-title":"Seasonal variation in detection of oesophageal eosinophilia and eosinophilic oesophagitis","volume":"42","author":"Jensen","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.7","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.mayocp.2015.07.015","article-title":"The role of environmental exposures in the etiology of eosinophilic esophagitis: a systematic review","volume":"90","author":"Green","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.08.004"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.9","doi-asserted-by":"publisher","DOI":"10.1159\/000355161"},{"key":"2025042703070504000_2018.mar15_1.bcr-2017-223465.10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jaci.2013.04.053","article-title":"Eosinophilic esophagitis treated with immunotherapy to dust mites","volume":"132","author":"Ramirez","year":"2013","journal-title":"J Allergy Clin Immunol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-223465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:07:12Z","timestamp":1745748432000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-223465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,15]]},"references-count":10,"alternative-id":["10.1136\/bcr-2017-223465"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-223465","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,15]]}}}