{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:38:12Z","timestamp":1762177092557,"version":"3.40.4"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,5,18]]},"abstract":"<jats:p>A 17-year-old woman, with a history of three operations on the upper gut in early life and intermittent diarrhoea, presented with a history of epistaxis and leg ecchymosis for the previous 3\u2009months. Initial investigation revealed mild anaemia, low serum albumin, moderately elevated aminotransferases and an exceedingly prolonged prothrombin time (PT) which was promptly shortened to normal by intravenous vitamin K. Additional investigations revealed a grossly abnormal glucose hydrogen breath test, a dilated duodenum and deficiencies of vitamins A, D and E. Repeated courses of antimicrobial agents caused prompt but transient shortening of PT and eventually a duodenal\u2013jejunal anastomosis was performed. Since then, up to 36 months later, the patient has been in good general health and PT has been consistently normal with no vitamin K supplementation. Small intestinal bacterial overgrowth has previously been associated with several conditions but this is the first description of its association with vitamin K-responsive coagulopathy.<\/jats:p>","DOI":"10.1136\/bcr-2017-223531","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T05:55:12Z","timestamp":1528350912000},"page":"bcr-2017-223531","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Small intestinal bacterial overgrowth (SIBO) and vitamin K-responsive coagulopathy: a previously unrecorded association"],"prefix":"10.1136","volume":"2018","author":[{"given":"Ricardo Brandt","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lourdes Candolo","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Ernesto Almeida","family":"Troncon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-1045","authenticated-orcid":false,"given":"Jorge","family":"Elias Jr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.046"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12456"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.11.032"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.4","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.06.2008.0008"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.5","first-page":"642","article-title":"Bleeding tendency in an adolescent with chronical small bowel obstruction","volume":"21","author":"Visuthranukul","year":"2012","journal-title":"Asia Pac J ClinNutr"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ajg.2017.46","article-title":"Hydrogen and methane-based breath testing in gastrointestinal disorders: the North American Consensus","volume":"112","author":"Rezaie","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.7","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12479"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.8","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jhep.2012.11.023","article-title":"The gut microbiota and the iver.Pathophysiological and clinical implications","volume":"258","author":"Quigley","year":"2013","journal-title":"J Hepatol"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.9","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0016-5085(79)91337-4","article-title":"Small intestine bacterial overgrowth","volume":"76","author":"King","year":"1979","journal-title":"Gastroenterology"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.10","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2009"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.11","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.85"},{"key":"2025042703495916000_2018.jun06_1.bcr-2017-223531.12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.020"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-223531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:50:05Z","timestamp":1745751005000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-223531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,6]]},"references-count":12,"alternative-id":["10.1136\/bcr-2017-223531"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-223531","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,6,6]]}}}