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Subsequently, a full-body positron emission tomography contrast enhanced computer tomography revealed hypermetabolic lesions of her axial (excluding skull) and appendicular skeleton. In the head and neck region, left mandibular foramen and oropharynx bilaterally showed increased metabolism suggestive of tumour metastasis. The diagnosis was numb chin syndrome secondary to mandibular metastasis. Apart from supportive treatment, she was started on palliative chemotherapy and radiotherapy. At the time of discharge, there were no active complaints other than the aforementioned hypoesthesia.<\/jats:p>","DOI":"10.1136\/bcr-2017-223586","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T06:25:18Z","timestamp":1526365518000},"page":"bcr-2017-223586","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Numb chin syndrome: an ominous sign of mandibular metastasis"],"prefix":"10.1136","volume":"2018","author":[{"given":"Abdul","family":"Razak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bee See","family":"Goh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7383-2962","authenticated-orcid":false,"given":"Jothi Raamahlingam","family":"Rajaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abd Jabar","family":"NAZIMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-4-52"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijscr.2017.01.001","article-title":"Numb chin syndrome as a sign of mandibular metastasis: A case report","volume":"31","author":"Aerden","year":"2017","journal-title":"Int J Surg Case Rep"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00050-0"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.4","doi-asserted-by":"crossref","first-page":"805.e1","DOI":"10.1016\/j.ajem.2016.11.055","article-title":"Numb chin syndrome: A harbinger of tumor progression or relapse","volume":"35","author":"Balamurugan","year":"2017","journal-title":"Am J Emerg Med"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.5","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90167-2"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.6","first-page":"257","article-title":"Bone metastasis to the mandible in rectal cancer and a review of the literature","volume":"8","author":"Probyn","year":"2015","journal-title":"Journal of Pain Management"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12105-014-0591-z","article-title":"Metastatic tumors to the jaws and mouth","volume":"8","author":"Hirshberg","year":"2014","journal-title":"Head Neck Pathol"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.8","first-page":"E616","article-title":"Malignant mental nerve neuropathy: systematic review","volume":"13","author":"Gal\u00e1n Gil","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.09.012"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/0973-029X.164538","article-title":"Numb chin syndrome associated with metastatic invasive ductal carcinoma of breast","volume":"19","author":"Sudha","year":"2015","journal-title":"J Oral Maxillofac Pathol"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/jiaomr.JIAOMR_2_16","article-title":"Numb chin syndrome as a primary presentation of metastatic breast cancer","volume":"29","author":"Sahni","year":"2017","journal-title":"\u00a0J Indian Acad Oral Med Radiol"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.12","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1097\/SCS.0b013e318231e5a1","article-title":"Metastatic prostate adenocarcinoma associated with numb chin syndrome","volume":"22","author":"Soares","year":"2011","journal-title":"J Craniofac Surg"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.13","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.tripleo.2008.05.063","article-title":"Widening of the inferior alveolar canal: a case report with atypical lymphocytic infiltration of the nerve","volume":"106","author":"Vartiainen","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"2025042703375474000_2018.may14_1.bcr-2017-223586.14","unstructured":"Ai CJ , Jabar NA , Lan TH , et al . 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