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Interestingly, she was noted to have reactive anti-hepatitis E virus (HEV) IgM at initial presentation followed by anti-HEV IgG positivity a month later. The serological pattern confirmed the diagnosis of acute hepatitis E. The combination of antiviral therapy for hepatitis B and resolution of acute hepatitis E resulted in normalisation of serum aminotransferases. This case illustrates the importance of taking a careful history and having a high index of suspicion for various aetiologies when evaluating patients with reactivation of CHB.<\/jats:p>","DOI":"10.1136\/bcr-2017-223616","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T06:25:12Z","timestamp":1528698312000},"page":"bcr-2017-223616","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Acute hepatitis E superinfection leading to chronic hepatitis B 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