{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:07:59Z","timestamp":1782601679269,"version":"3.54.5"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,7,28]]},"abstract":"<jats:p>A 58-year-old Caucasian male presented with left periorbital oedema extending to the nasal area for 1\u2009year along with nasal discharge for 1\u2009month. Lab work was significant for positive cytoplasmic antineutrophil cytoplasmic antibodies. CT scan showed solid mass along the nasal soft tissue with bony nasal destruction. A CT scan of the thorax was performed to rule out granulomatosis with polyangiitis and showed multiple pulmonary nodules. Biopsies of the nasal mass and lung nodule were performed which showed fragments of fibrosis with spindle cell proliferation consistent with eosinophilic angiocentric fibrosis (EAF). EAF is a very rare disease, recently described as a subtype of immunoglobulin G4-related disease. A few rare cases of EAF involving the structures of the orbit have been reported in the literature.<\/jats:p>","DOI":"10.1136\/bcr-2017-223675","type":"journal-article","created":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T09:55:02Z","timestamp":1533808502000},"page":"bcr-2017-223675","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Eosinophilic angiocentric fibrosis : a sino-orbital masquerader"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-0967","authenticated-orcid":false,"given":"Nicole","family":"Legare","sequence":"first","affiliation":[{"name":"University of Central Florida, College of Medicine, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Frosh","sequence":"additional","affiliation":[{"name":"Rheumatology, Orlando VA Medical Center, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Pathology, Orlando VA Medical Center, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son T","family":"Ho","sequence":"additional","affiliation":[{"name":"Ophthalmology, Orlando VA Medical Center, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318213889e"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuchi.2015.10.002","article-title":"Unilateral orbital mass as an unusual presentation of IgG4-related disease","volume":"62","author":"Rammeh","year":"2016","journal-title":"Neurochirurgie"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.3","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-015-0620-6"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.11.008"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.5","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31829165ad"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.6","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1002\/hed.23396","article-title":"Primary orbital eosinophilic angiocentric fibrosis with intranasal extension","volume":"36","author":"Karligkiotis","year":"2014","journal-title":"Head Neck"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.7","doi-asserted-by":"publisher","DOI":"10.1080\/01676830600674544"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.09.035"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1442-9071.2008.01725.x","article-title":"Eosinophilic angiocentric fibrosis of the orbit","volume":"36","author":"Kiratli","year":"2008","journal-title":"Clin Exp Ophthalmol"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.anl.2016.10.011","article-title":"Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease","volume":"44","author":"Takano","year":"2017","journal-title":"Auris Nasus Larynx"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204907"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/ICU.0000000000000204","article-title":"Management of orbital IgG4-related disease","volume":"26","author":"Glass","year":"2015","journal-title":"Curr Opin Ophthalmol"},{"key":"2025082703474998000_2018.aug09_2.bcr-2017-223675.14","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1017\/S0022215114002552","article-title":"Eosinophilic angiocentric fibrosis of the nose and sinuses","volume":"128","author":"Rimmer","year":"2014","journal-title":"J Laryngol Otol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-223675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:47:59Z","timestamp":1756291679000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-223675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,9]]},"references-count":14,"alternative-id":["10.1136\/bcr-2017-223675"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-223675","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,9]]}}}