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General symptoms such as fever, arthralgia, myalgia or bone marrow depression (leucopaenia) are seen less frequently. We describe the case of a 33-year-old woman with chronic Chagas disease who presented with acute gingival bleeding and severe thrombocytopaenia, probably related to benznidazole treatment. Temporal association with drug initiation and recovery after treatment withdrawal were demonstrated. Clinicians should be aware of the possible association between immune thrombocytopaenia and benznidazole, even though the pathogenesis remains unclear at present.<\/jats:p>","DOI":"10.1136\/bcr-2017-223788","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T09:25:07Z","timestamp":1522142707000},"page":"bcr-2017-223788","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Severe immune thrombocytopaenia in a patient taking benznidazole for chronic Chagas disease"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-8616","authenticated-orcid":false,"given":"Clara","family":"Crespillo-And\u00fajar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Calbacho Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca F","family":"Norman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A","family":"P\u00e9rez-Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"2025042703133908000_2018.mar27_1.bcr-2017-223788.1","unstructured":"WHO. 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