{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:47:47Z","timestamp":1768535267726,"version":"3.49.0"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,3,22]]},"abstract":"<jats:p>We report a case of 56-year-old man presented to us with chief complaints of frothy urine and leg swelling. A urinalysis revealed nephrotic-range proteinuria. Haematological investigations revealed thrombocytosis, leucocytosis and peripheral blood smear showed a leucoerythroblastic picture. JAK 2 mutation was positive. To confirm the diagnosis of myeloproliferative neoplasm, bone marrow biopsy was done, which was suggestive of primary myelofibrosis. The patient underwent kidney biopsy due to rapidly declining renal function and persistent proteinuria, which was suggestive of focal segmental glomerulosclerosis. Early glomerulopathy is rare in myeloproliferative neoplasm, and aggressive follow-up is required to prevent progression of kidney disease.<\/jats:p>","DOI":"10.1136\/bcr-2017-223803","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T06:10:37Z","timestamp":1525414237000},"page":"bcr-2017-223803","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Focal segmental glomerulosclerosis in a patient with prefibrotic primary myelofibrosis"],"prefix":"10.1136","volume":"2018","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9524-5278","authenticated-orcid":false,"given":"Gopal Krishana","family":"Bohra","sequence":"first","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durga Shankar","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of General Medicine, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Bajpai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Purohit","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199905)61:1<10::AID-AJH3>3.0.CO;2-I"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.2","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/ajh.24592","article-title":"Primary myelofibrosis: 2017 update on diagnosis, risk-stratification, and management","volume":"91","author":"Tefferi","year":"2016","journal-title":"Am J Hematol"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.3","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/S0022-5347(17)37566-3","article-title":"Idiopathic myelofibrosis with myeloid metaplasia involving the renal pelves, ureters and bladder","volume":"147","author":"Oesterling","year":"1992","journal-title":"J Urol"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0145-2126(97)00049-0","article-title":"Secondary amyloidosis in the course of idiopathic myelofibrosis","volume":"21","author":"Ferhano\u011flu","year":"1997","journal-title":"Leuk Res"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3346\/jkms.2000.15.4.460","article-title":"CT findings of extramedullary hematopoiesis in the thorax, liver and kidneys, in a patient with idiopathic myelofibrosis","volume":"15","author":"Kwak","year":"2000","journal-title":"J Korean Med Sci"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/08860220903573286","article-title":"Focal segmental glomerulosclerosis associated with idiopathic myelofibrosis","volume":"32","author":"Kaygusuz","year":"2010","journal-title":"Ren Fail"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.147"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12882-015-0121-6","article-title":"Primary myelofibrosis associated glomerulopathy: significant improvement after therapy with ruxolitinib","volume":"16","author":"Rajasekaran","year":"2015","journal-title":"BMC Nephrol"},{"key":"2025082701503958000_2018.may03_1.bcr-2017-223803.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00574.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-223803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:50:48Z","timestamp":1756284648000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-223803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,4]]},"references-count":9,"alternative-id":["10.1136\/bcr-2017-223803"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-223803","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,4]]}}}