{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:21:37Z","timestamp":1761844897627,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,5,23]]},"abstract":"<jats:p>Chronic Myeloid Leukaemia (CML) presenting with isolated Central Nervous System (CNS) blast crisis is an uncommon entity. A 22-year-old man, diagnosed with chronic phase CML in 2011 and was in haematological and cytogenetic remission until July 2016, had acute onset headache and vomiting with meningeal signs and was admitted elsewhere, investigated by brain imaging and cerebrospinal fluid (CSF) analysis and suspected to have tubercular meningitis, for which steroids and antitubercular medications were started. The patient\u2019s sensorium further deteriorated, and Ventriculoperitoneal shunt surgery was done for hydrocephalus by a neurosurgeon. After 2\u2009months of the illness, he was admitted to our hospital with a persistent headache, vomiting and altered sensorium. CSF for cytospin confirmed myeloid blasts. He was still in haematological remission. So, a diagnosis of isolated CNS blast crisis was made. The patient was started on triple intrathecal chemotherapy and cranial radiotherapy. He had improvement with treatment and is still in remission.<\/jats:p>","DOI":"10.1136\/bcr-2017-223923","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T09:20:04Z","timestamp":1528795204000},"page":"bcr-2017-223923","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Central nervous system blast crisis of chronic myeloid leukaemia misdiagnosed as tubercular meningitis"],"prefix":"10.1136","volume":"2018","author":[{"given":"Banshi Lal","family":"Kumawat","sequence":"first","affiliation":[{"name":"Department of Neurology, Sawai Mansingh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra Mohan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sawai Mansingh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-1589","authenticated-orcid":false,"given":"Pankaj Kumar","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sawai Mansingh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sawai Mansingh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.1","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ajh.2830430104","article-title":"High incidence of meningeal leukemia in lymphoid blast crisis of chronic myelogenous leukemia","volume":"43","author":"Saikia","year":"1993","journal-title":"Am J Hematol"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.3","doi-asserted-by":"publisher","DOI":"10.1002\/hon.737"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-380147"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.5","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9352-0"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/dc.21795","article-title":"Fluorescent in situ hybridization diagnosis of extramedullary nodal blast crisis","volume":"41","author":"Jin","year":"2013","journal-title":"Diagn Cytopathol"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe030009"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03881.x"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.9","first-page":"1149","article-title":"Isolated central nervous system relapse in two patients with BCR-ABL-positive acute leukemia while receiving a next-generation tyrosine kinase inhibitor","volume":"28","author":"Gaur","year":"2014","journal-title":"In Vivo"},{"key":"2025082702484597000_2018.jun11_2.bcr-2017-223923.10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4172\/2329-6917.1000212","article-title":"Isolated CNS blast crisis of CML in a patient on dasatinib therapy","volume":"4","author":"Al blooshi","year":"2016","journal-title":"J Leuk"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-223923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:48:55Z","timestamp":1756288135000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-223923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":10,"alternative-id":["10.1136\/bcr-2017-223923"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-223923","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,6,12]]}}}