{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:16:43Z","timestamp":1770509803911,"version":"3.49.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,5,15]]},"abstract":"<jats:p>We report a case of Cogan\u2019s syndrome presenting as fever of unknown origin in a 31-year-old woman who was admitted to the hospital with a 7-week history of fever, night sweats and other constitutional symptoms. The diagnosis remained elusive despite numerous investigations, and the patient subsequently developed rash, episcleritis, dizziness and sensorineural hearing loss. While initially thought to be a postinflammatory response to a previous infection, confirmation of the rash as a vasculitis together with the audiovestibular and ocular involvement led to a clinical diagnosis of Cogan\u2019s syndrome. This was further corroborated by resolution of her symptoms once immunosuppressive therapy was instituted. Early recognition of Cogan\u2019s syndrome is crucial to reducing the risk of serious complications through the timely initiation of treatment.<\/jats:p>","DOI":"10.1136\/bcr-2017-224031","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T08:35:46Z","timestamp":1528101346000},"page":"bcr-2017-224031","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Fever of unknown origin: a challenging case"],"prefix":"10.1136","volume":"2018","author":[{"given":"Sarah","family":"Vella","sequence":"first","affiliation":[{"name":"Medicine, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Coleiro","sequence":"additional","affiliation":[{"name":"Rheumatology, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Mallia Azzopardi","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.15-3-280"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31802fe858"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ajme.2014.07.001","article-title":"Cogan\u2019s Syndrome in a Jordanian patient: A case report","volume":"50","author":"Al-Shagahin","year":"2014","journal-title":"Alexandria Journal of Medicine"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.4","first-page":"139","article-title":"Atypical Cogan\u2019s Syndrome: case report of an oculoaudiovestibular disease","volume":"2","author":"Belhoucha","year":"2014","journal-title":"American Journal of Medical Case Reports"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.5","doi-asserted-by":"publisher","DOI":"10.4065\/81.4.483"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.6","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv128"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.7","doi-asserted-by":"crossref","unstructured":"Zulian F , Sari M , Zannin ME . Cogan\u2019s Syndrome. Parnham MJ , Compendium of inflammatory diseases. Basel, Switzerland: Springer, 2016:332\u20139.","DOI":"10.1007\/978-3-7643-8550-7_204"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2007.07.015"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.9","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198011000-00003"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.10","first-page":"108","article-title":"A shifty diagnosis: Cogan\u2019s syndrome. A case report and review of the literature","volume":"29","author":"Migliori","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"2025082804560880000_2018.jun01_1.bcr-2017-224031.11","first-page":"8","article-title":"Typical and Atypical Cogan\u2019s Syndrome: 7 Cases and Review of the Literature","volume":"1","author":"Belghmidi","year":"2014","journal-title":"Neuro-Ophthalmology & Visual Neuroscience"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-224031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:56:13Z","timestamp":1756382173000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-224031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":11,"alternative-id":["10.1136\/bcr-2017-224031"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-224031","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,4]]}}}