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The clinical picture mimicked Creutzfeldt-Jakob disease (CJD), but we could rule out this diagnosis by means of cerebrospinal fluid (CSF) analysis, which showed normal level of tau protein and A\u03b2<jats:sub>1-42<\/jats:sub>, being also negative for CSF 14-3-3 protein. A complete clinical recovery was observed after the discontinuation of antidepressants. So far, some cases of drug-induced CJD-like syndrome have been described. In our experience, early CSF analysis shows high diagnostic usefulness in order to exclude CJD.<\/jats:p>","DOI":"10.1136\/bcr-2018-224314","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T17:19:47Z","timestamp":1545153587000},"page":"e224314","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Drug-induced Creutzfeldt-Jakob disease-like syndrome: early CSF analysis as useful tool for differential diagnosis"],"prefix":"10.1136","volume":"11","author":[{"given":"Federico","family":"Paolini Paoletti","sequence":"first","affiliation":[{"name":"Section of Neurology, Department of Medicine, Universita degli Studi di Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Di Gregorio","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine, Universita degli Studi di Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine, Universita degli Studi di Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Neurology - 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